Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals
Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals
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DOI：
10.1073/pnas.0606216103
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发表时间：
2006-11-14
影响因子：
11.1
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
--
作者：
Stewart, Matthew E.;Mack, Nathan H.;Rogers, John A.
我们开发了一类准三维等离子体晶体，它由多层、规则的亚波长金属纳米结构阵列组成。这些晶体的光学传输光谱的复杂，高度敏感的结构使它们特别适合于传感应用。再加上光学响应的定量电动力学建模，它们可以对分子结合事件进行全多波长光谱检测，其灵敏度对应于单层的一小部分。由软纳米压印技术形成的晶体的高度空间均匀性，提供了以微米空间分辨率在大面积上成像结合事件的能力。这些特点，加上紧凑的外形因素，低成本的制造过程，简单的读出装置，以及直接集成到微流体网络和阵列的能力，表明这些设备在无标签生物分析检测系统中的前景。
We developed a class of quasi-3D plasmonic crystal that consists of multilayered, regular arrays of subwavelength metal nanostructures. The complex, highly sensitive structure of the optical transmission spectra of these crystals makes them especially well suited for sensing applications. Coupled with quantitative electrodynamics modeling of their optical response, they enable full multiwavelength spectroscopic detection of molecular binding events with sensitivities that correspond to small fractions of a monolayer. The high degree of spatial uniformity of the crystals, formed by a soft nanoimprint technique, provides the ability to image binding events over large areas with micrometer spatial resolution. These features, together with compact form factors, low-cost fabrication procedures, simple readout apparatus, and ability for direct integration into microfluidic networks and arrays, suggest promise for these devices in label-free bioanalytical detection systems.