CAN ETHNOPHARMACOLOGY CONTRIBUTE TO THE DEVELOPMENT OF ANTIVIRAL DRUGS
CAN ETHNOPHARMACOLOGY CONTRIBUTE TO THE DEVELOPMENT OF ANTIVIRAL DRUGS
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DOI：
10.1016/0378-8741(91)90112-q
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发表时间：
1991-04-01
影响因子：
5.4
通讯作者：
VANDENBERGHE, DA
中科院分区：
文献类型：
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作者：
VLIETINCK, AJ;VANDENBERGHE, DA
近年来，在细胞培养和实验动物中发现了许多具有强大抗病毒活性的化合物，但只有少数化合物被西方卫生当局批准用于临床。然而，其中一些化合物目前正在进行临床前或临床评估，寻找新的有趣的抗病毒药物的前景是很有希望的。在这些抗病毒物质中，有几种从传统医药中使用的植物中分离出来的天然化合物，包括多糖、黄酮类、萜类、生物碱、酚类和氨基酸。其中一些植物化合物表现出独特的抗病毒作用机制，是进一步临床研究的良好候选者。以下是对目前用于检测植物提取物中抗病毒活性的植物筛选方法和体外和体内试验的简要总结。植物界作为新的抗病毒物质来源的重要性将通过介绍植物来源的抗鼻病毒和抗艾滋病毒药物的综述来说明。
In recent years, many compounds having potent antiviral activity in cell cultures and in experimental animals have been detected, but only a few have been approved by Western health authorities for clinical use. Nevertheless, some of these compounds are currently undergoing either preclinical or clinical evaluation, and perspectives for finding new interesting antiviral drugs are promising. Among these antiviral substances are several natural compounds isolated from plants used in traditional medicine including polysaccharides, flavonoids, terpenes, alkaloids, phenolics and amino acids. Some of these plant compounds exhibit a unique antiviral mechanism of action and are good candidates for further clinical research. What follows is a brief summary of the selection methods of plants for antiviral screening and in vitro and in vivo assays, which are currently used for detecting this activity in plant extracts. The importance of the plant kingdom as a source of new antiviral substances will be illustrated by presenting a survey on plant-derived antirhinovirus and anti-HIV agents.