A study of candidate genotypes associated with dyspepsia in a US community
A study of candidate genotypes associated with dyspepsia in a US community
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DOI：
10.1111/j.1572-0241.2006.00481.x
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发表时间：
2006-03-01
影响因子：
9.8
通讯作者：
Urrutia, R
中科院分区：
文献类型：
--
作者：
Camilleri, CE;Carlson, PJ;Urrutia, R
背景：遗传易感性在消化不良发生发展中的作用尚不清楚。最近，GNβ3的CC基因与消化不良有显著的相关性。目的：在一个美国社区的样本中，探讨改变肾上腺素、5-羟色胺、CCK和G蛋白功能的候选基因与消化不良的关系。方法：在随机选择完成有效问卷的社区受访者中，确定消化不良患者和健康对照。其他疾病通过面对面的病史和体检排除。研究了α(2A)、α(2C)、5-HT1A、5-HT2A、5-HT2C、CCK-1受体和CCK启动子、GNβ3蛋白和SERT-P等候选基因的多态性。用Fisher‘s精确检验评估基因多态性与进餐相关或非进餐相关的消化不良、高躯体症状评分和躯体化的关系。结果：来自奥姆斯特县的41名消化不良患者和47名健康对照均可获得DNA。与进食无关的社区消化不良与纯合子GNβ3蛋白825T和C等位基因相关。与进食相关的消化不良没有显著的关联。在罗马II亚型中，相同的基因与运动障碍样和其他消化不良相关。当被认为是单因素时，较高的躯体化评分与任何候选基因都没有显著的相关性。结论：在美国的一项社区研究中，与进餐无关的消化不良与GNβ3蛋白的825T或C等位基因有关。控制肾上腺素能、5-羟色胺能和CCK能功能的候选基因似乎与消化不良无关。
BACKGROUND: The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GN beta 3.AIM: To explore the association of candidate genotypes altering adrenergic, serotonergic, CCKergic, and G protein functions, and dyspepsia in a sample from a U.S. community.METHODS: Dyspeptics and healthy controls were identified among community respondents who had been randomly selected to complete validated questionnaires. Other diseases were excluded by face-to-face history and physical examination. Polymorphisms of candidate genes for alpha(2A), alpha(2C), 5-HT1A, 5-HT2A, 5-HT2C, CCK-1 receptors and CCK promoter, GN beta 3 protein, and SERT-promoter (SERT-P) were studied. The association between polymorphisms and meal-related or meal-unrelated dyspepsia, high somatic symptom scores, and somatization were evaluated using Fisher's exact test.RESULTS: DNA was available from 41 dyspeptics and 47 healthy controls from Olmsted County. Community dyspepsia unrelated to meals was associated with both homozygous GN beta 3 protein 825T and C alleles. There were no significant associations with meal-related dyspepsia. Using Rome II subgroups, the same genotype was associated with dysmotility-like and other dyspepsia. Higher somatization scores were not significantly associated with any of the candidate genes when considered as single factors.CONCLUSION: Meal-unrelated dyspepsia in a U.S. community study is associated with the homozygous 825T or C alleles of GN beta 3 protein. Candidate genes controlling adrenergic, serotonergic, and CCKergic functions do not appear to be associated with dyspepsia.