Participation of the olfactory system in the control of approach behavior of the female rat to the male
Participation of the olfactory system in the control of approach behavior of the female rat to the male
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DOI：
10.1016/0031-9384(90)90078-i
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发表时间：
1990-04
影响因子：
2.9
通讯作者：
P. Romero;C. Beltramino;H. Carrer
中科院分区：
文献类型：
--
作者：
P. Romero;C. Beltramino;H. Carrer
测量雌性动物在靠近饲养正常雄性动物或去势雄性动物的笼舍的开放区域中所花费的时间量，以量化雌性动物与性活跃雄性动物（向雄性化）身体接近的趋势。以100 μ g苯甲酸雌二醇/kg b.wt.预处理的完整动情前期或卵巢切除雌性动物(EB)或EB +2mg孕酮/kg b.wt. (P)在性活跃的（完整的）雄性动物附近花费的时间显著多于在切除睾丸的雄性动物附近花费的时间。为了确定嗅觉线索是否足以使雌性大鼠区分完整和去势雄性，将雄性大鼠从刺激笼中取出，将弄脏的垫料留在原位。用EB或EB + P引发的卵巢切除大鼠明显喜欢接近完整雄性动物居住的笼子。没有明显的偏好后，切断嗅神经在发情前期大鼠或卵巢切除大鼠与EB加P。切除犁鼻器也抑制偏好。这些结果表明，嗅觉输入是必要的和足够的向雄性发生，并建议，辅助嗅觉系统参与了嗅觉信号的分析，用于确定未来的性伴侣的内分泌状态的雌性大鼠。在另一组动物中，研究表明，杏仁核后内侧皮质的破坏也抑制了对完整雄性动物的偏好。这一结构可能是对雌性大鼠性行为动机控制的嗅觉输入进行分析和整合的中继站。所有病变均不影响探索性活动或性接受性，测量为活跃男性的脊柱前凸评分至10分。
The amounts of time spent by females in the sector of an open field close to the cage housing a normal male or a castrated male were measured in order to quantitate the tendency of the female to reach physical proximity to a sexually active male (androtropism). Intact proestrous or ovariectomized females primed with 100 μg of estradiol benzoate/kg b.wt. (EB) or EB plus 2 mg progesterone/kg b.wt. (P) spent significantly more time close to the sexually active (intact) male than in the proximity of the orchidectomized male. In order to determine whether olfactory clues were sufficient for female rats to distinguish between intact and castrated males, the males were removed from the stimulus cages, leaving the soiled bedding in place. Ovariectomized rats primed with EB or EB plus P clearly preferred proximity to the cage where the intact male had been living. No preference was evident after transection of olfactory nerves in proestrous rats or in ovariectomized rats primed with EB plus P. Resection of the vomeronasal organ also suppressed preference. These results indicate that olfactory input is necessary and sufficient for androtropism to occur, and suggest that the accesory olfactory system is involved in the analysis of olfactory signals used by female rats to identify the endocrine status of prospective sexual partners. In a different group of animals, it was demonstrated that destruction of the posteromedial cortical amygdaloid nucleus also suppressed preference for the intact male. It is proposed that this structure serves as a relay station for the analysis and integration of olfactory input significant for the motivational control of sexual behavior in the female rat. None of the lesions affected either exploratory activity or sexual receptivity measured as the lordosis score to ten mounts by active males.