The gut microbiota is an emerging target for improving brain health during ageing.
The gut microbiota is an emerging target for improving brain health during ageing.
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DOI：
10.1017/gmb.2022.11
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发表时间：
2023-01-01
期刊：
影响因子：
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通讯作者：
Cox, Laura Michelle
中科院分区：
文献类型：
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作者：
Boehme, Marcus;Guzzetta, Katherine Elizabeth;Cox, Laura Michelle
肠道微生物群在维持宿主整个生命周期的健康和体内平衡方面发挥着至关重要的作用，包括通过其影响大脑功能和调节衰老过程中的行为的能力。研究表明，尽管实际年龄相同，但生物衰老率却存在差异，包括神经退行性疾病的发展，这表明环境因素可能在决定衰老健康结果方面发挥重要作用。最近的证据表明，肠道微生物群可能是改善大脑衰老症状和促进健康认知的潜在新目标。这篇综述强调了当前关于肠道微生物群与宿主大脑衰老之间关系的知识，包括对与年龄相关的神经退行性疾病的潜在贡献。此外，我们评估了基于肠道微生物群的策略可能作为干预机会的关键领域。
The gut microbiota plays crucial roles in maintaining the health and homeostasis of its host throughout lifespan, including through its ability to impact brain function and regulate behaviour during ageing. Studies have shown that there are disparate rates of biologic ageing despite equivalencies in chronologic age, including in the development of neurodegenerative diseases, which suggests that environmental factors may play an important role in determining health outcomes in ageing. Recent evidence demonstrates that the gut microbiota may be a potential novel target to ameliorate symptoms of brain ageing and promote healthy cognition. This review highlights the current knowledge around the relationships between the gut microbiota and host brain ageing, including potential contributions to age-related neurodegenerative diseases. Furthermore, we assess key areas for which gut microbiota-based strategies may present as opportunities for intervention.