Awakening cortisol responses are influenced by health status and awakening time but not by menstrual cycle phase
Awakening cortisol responses are influenced by health status and awakening time but not by menstrual cycle phase
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DOI：
10.1016/s0306-4530(02)00008-2
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发表时间：
2003-01-01
影响因子：
3.7
通讯作者：
Kirschbaum, C
中科院分区：
文献类型：
--
作者：
Kudielka, BM;Kirschbaum, C
最近的证据表明，在健康的年轻人中，游离皮质醇对觉醒的反应受到觉醒时间的影响（Edwards等人，2001年）。为了进一步研究这种关联，179名大年龄范围（4-75岁）的社区居民参与了本研究。样本包括99名妇女、67名男子和13名儿童。受试者被指示在觉醒后以及之后的15、30、45和60分钟直接获取唾液样本。第一个分析显示，唾液皮质醇配置文件在健康受试者醒来后，不同的配置文件中报告的健康问题或慢性疾病（p = 0.02）与健康受试者表现出更大的皮质醇反应。因此，以下分析仅包括健康受试者。受试者在0455至1203 h之间醒来。觉醒时间强烈影响早晨皮质醇水平的过程。两个唤醒组的皮质醇谱差异显著（p
Recent evidence dsuggested that the free cortisol response to awakening is influenced by awakening time in healthy younger adults (Edwards et al., 2001). In order to investigate this association further, 179 community-dwelling subjects of a large age range (4-75 yrs) participated in the present study. The sample consisted of 99 women, 67 men and 13 children. Subjects were instructed to obtain saliva samples directly after awakening as well as 15, 30, 45, and 60 minutes thereafter. A first analysis revealed that salivary cortisol profiles after awakening in healthy subjects differed from profiles in subjects who reported health problems or a chronic disease (p = 0.02) with healthy subjects showing a larger cortisol response. Therefore, only healthy subjects were included in the following analyses.Subjects woke up between 0455 and 1203 h. Time of awakening strongly influenced the course of morning cortisol levels. Cortisol profiles differed significantly between two wake-up groups (p