Pubertal growth and development and prenatal and lactational exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene
Pubertal growth and development and prenatal and lactational exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene
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DOI：
10.1016/s0022-3476(00)90012-x
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发表时间：
2000-04-01
影响因子：
5.1
通讯作者：
Rogan, WJ
中科院分区：
文献类型：
--
作者：
Gladen, BC;Ragan, NB;Rogan, WJ
目的：多氯联苯（PCBs）和二氯二苯二氯乙烯（DDE）是普遍存在的有毒环境污染物。产前和生命早期的暴露影响实验动物的青春期事件。我们研究了是否产前或哺乳期暴露于背景水平的多氯联苯或DDE与青春期生长和发育的改变在human.Study design：随访的594名儿童从现有的北卡罗来纳州队列的产前和哺乳期暴露以前进行了测量。身高，体重和青春期发育阶段进行了评估，通过每年的邮件questionnaire.Results：身高的男孩在青春期增加与经胎盘接触DDE，因为没有调整身高的体重;调整后的平均值为那些最高的风险（母体浓度4+ ppm的脂肪）高6.3厘米，6.9公斤大于那些最低的（0至1 ppm）。对达到青春期阶段的年龄没有影响。哺乳期接触DDE没有明显的影响，也没有经胎盘或哺乳期接触多氯联苯。最高的经胎盘PCB暴露的女孩比其他女孩的身高重5.4公斤，但只有当分析仅限于白色girls.Conclusions：产前暴露在背景水平mag影响青春期的身体大小。
Objectives: Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) are ubiquitous toxic environmental contaminants. Prenatal and early life exposures affect pubertal events in experimental animals. We studied whether prenatal or lactational exposures to background levels of PCBs or DDE were associated with altered pubertal grow th and development in humans.Study design: Follow-up of 594 children from an existing North Carolina cohort whose prenatal and lactational exposures had previous been measured. Height, weight, and stage of pubertal development were assessed through annual mail questionnaires.Results: Height of boys at puberty increased with transplacental exposure to DDE, as did weight adjusted for height; adjusted means for those with the highest exposures (maternal concentration 4+ ppm fat) were 6.3 cm taller and 6.9 kg larger than those with the lowest (0 to 1 ppm). There was no effect on the ages at which pubertal stages were attained. Lactational exposures to DDE had no apparent effects; neither did transplacental or lactational exposure to PCBs. Girls with the highest transplacental PCB exposures were heavier for their heights than other girls by 5.4 kg, but differences were significant only if the analysis was restricted to white girls.Conclusions: Prenatal exposures at background levels mag affect body size at puberty.