STRESS AND MORTALITY IN A SMALL MARSUPIAL (ANTECHINUS-STUARTII, MACLEAY)
STRESS AND MORTALITY IN A SMALL MARSUPIAL (ANTECHINUS-STUARTII, MACLEAY)
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DOI：
10.1016/0016-6480(80)90122-7
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发表时间：
1980-01-01
影响因子：
2.7
通讯作者：
LEE, AK
中科院分区：
文献类型：
--
作者：
BRADLEY, AJ;MCDONALD, IR;LEE, AK
本文探讨了肾上腺皮质活动增强在雄性斯氏沼虾交配后总死亡率中所起的作用。雄鼠在交配前血浆雄激素浓度的逐渐升高与日益增长的攻击性行为和血浆中皮质类固醇结合球蛋白浓度的逐渐下降有关。在交配期，血浆CBG浓度下降的速度明显增加，血浆总皮质类固醇浓度上升到MCBC[血浆高亲和力皮质类固醇结合力]以上，因此在雄性死亡前血浆游离皮质类固醇浓度急剧上升。虽然雌性在交配期血浆CBG浓度也有所下降，但血浆总糖皮质激素浓度略有升高，但血浆游离皮质激素浓度在交配后、哺乳期变化不大。圈养雄鼠的去势导致其血浆CBG浓度显着升高，而注射睾酮或ACTH则可抑制其浓度。男性死亡前的免疫能力和血清免疫球蛋白浓度显著降低。尸检发现寄生虫和微生物侵袭性增加的证据，以及严重的消化道出血性溃疡。这些效应都可以通过注射皮质醇醋酸酯在圈养动物身上重现。交配时由攻击性相互作用引起的应激状态，由于血浆CBG的下降而加剧，导致雄性的免疫和炎症系统受到抑制，导致它们死于胃肠道出血以及寄生虫和微生物的入侵。
An investigation was made into the role of increased adrenocortical activity in the causation of the total postmating mortality of male A. stuartii, a small shrew-like marsupial. A progressive rise in plasma androgen concentration of the males up to the time of mating was associated with increasingly aggressive behavior and a progressive fall in plasma CBG [corticosteroid binding globulin] concentration. During the mating period, the rate of fall in plasma CBG concentration increased markedly and plasma total corticosteroid concentration rose above the MCBC [plasma high affinity corticosteroid binding capacity], so that there was a sharp rise in plasma free corticosteroid concentration just before the males died. Although the plasma CBG concentration of females also fell during the mating period, with a moderate increase in plasma total glucocorticoid concentration, there was only a slight increase in plasma-free corticosteroid concentration at that time and it did not change significantly during the postmating, lactation period. Castration of captive males caused a marked increase in their plasma CBG concentration and injection of testosterone or ACTH depressed it. There was a marked reduction in immunological competence and serum immunoglobulin concentration of the males just before their death. Postmortem examination revealed evidence of increased invasiveness of parasites and microorganisms, as well as severe hemorrhagic ulceration of the digestive tract. These effects could all be reproduced in captive animals by injection of cortisol acetate. A state of stress, induced by aggressive interactions at the time of mating and exacerbated by the fall in plasma CBG, results in suppression of the immune and inflammatory systems of the males, causing their death from gastrointestinal hemorrhage as well as invasion by parasites and microorganisms.