Association between periodontal disease and non-communicable diseases: A 12-year longitudinal health-examinee cohort study in South Korea.
Association between periodontal disease and non-communicable diseases: A 12-year longitudinal health-examinee cohort study in South Korea.
复制标题
DOI：
10.1097/md.0000000000007398
复制
发表时间：
2017-06
期刊：
影响因子：
1.6
通讯作者：
Choi SH
中科院分区：
文献类型：
--
作者：
Lee JH;Oh JY;Youk TM;Jeong SN;Kim YT;Choi SH
本研究以2002 - 2013年国民健康保险服务健康考试人群为研究对象，探讨牙周病与高血压、糖尿病、骨质疏松、脑梗塞、心绞痛、心肌梗塞、肥胖等非传染性疾病的关系。单变量和多变量logistic回归分析调整了随访期间的潜在混杂因素，包括年龄，性别，家庭收入，保险状况，居住地区，健康状况和合并症，用于估计比值比（OR）和95%置信区间（CI），以评估PD和NCD之间的相关性。我们入组了200，026例PD患者和154，824例口腔健康受试者。统计学上，在调整社会人口统计学和合并症因素后，发现PD与所调查的NCD之间存在显著相关性（脑梗死和心肌梗死除外）（P <0.05）。 尤其是肥胖（OR = 1.30，95%CI = 1.04-1.63，P = 0.022）、骨质疏松（OR = 1.22，95%CI = 1.18-1.27，P <0.001）和心绞痛（OR = 1.22，95%CI = 1.17-1.27，P <0.001）与PD显著正相关。 这项纵向队列研究提供的证据表明，PD患者患NCD的风险增加。需要进一步的研究来证实这种关联的可靠性，并阐明炎症通路在牙周炎发病机制中作为触发和介导机制的作用。
The National Health Insurance Service–Health Examinee Cohort during 2002 to 2013 was used to investigate the associations between periodontal disease (PD) and the following non-communicable diseases (NCDs): hypertension, diabetes mellitus, osteoporosis, cerebral infarction, angina pectoris, myocardial infarction, and obesity. Univariate and multivariate logistic regression analyses adjusting for potential confounders during the follow-up period—including age, sex, household income, insurance status, residence area, health status, and comorbidities—were used to estimated odds ratios (ORs) with 95% confidence intervals (CIs) in order to assess the associations between PD and NCDs. We enrolled 200,026 patients with PD and 154,824 subjects with a healthy oral status. Statistically, significant associations were found between PD and the investigated NCDs except for cerebral and myocardial infarction after adjusting for sociodemographic and comorbidity factors (P < .05). In particular, obesity (OR = 1.30, 95% CI = 1.04–1.63, P = .022), osteoporosis (OR = 1.22, 95% CI = 1.18–1.27, P < .001), and angina pectoris (OR = 1.22, 95% CI = 1.17–1.27, P < .001) were significantly and positively associated with PD. This longitudinal cohort study has provided evidence that patients with PD are at increased risk of NCDs. Further studies are required to confirm the reliability of this association and elucidate the role of the inflammatory pathway in periodontitis pathogenesis as a triggering and mediating mechanism.