Mixed and obstructive apneas are related to ventilatory oscillations in premature infants.
Mixed and obstructive apneas are related to ventilatory oscillations in premature infants.
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混合性和阻塞性呼吸暂停与早产儿的通气振荡有关。
DOI：
10.1152/jappl.1989.66.6.2818
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Stark,AR
中科院分区：
文献类型：
--
作者：
Waggener,TB;Frantz3rd,ID;Cohlan,BA;Stark,AR
在我们以前的研究14早产儿，呼吸暂停发生在最低阶段的摆动。呼吸暂停对应于鼻和口的气流停止，不能区分为中枢性、混合性或阻塞性。尚未发现与呼吸暂停相关的心率变化。为了确定呼吸暂停模式特征是否可以预测呼吸暂停的类型或呼吸暂停期间的心率变化，我们分析了早期研究中进行的胸壁运动和心率测量。将磁力计测量的胸壁运动与面罩和呼吸速度描记器测量的气流进行比较。潮气量、呼吸持续时间和通气量在逐个呼吸的基础上计算，转换为时间轴数据串，并用零相移数字带通滤波器梳进行滤波以检测呼吸模式。在182例持续时间大于或等于3 s的呼吸暂停中，55%为中心性呼吸暂停，31%为混合性呼吸暂停，14%为阻塞性呼吸暂停。所有三种类型的呼吸暂停都与呼吸振荡有关。多重线性和逻辑回归显示，呼吸暂停更可能是阻塞性的，当它是长的，当潜在的呼吸振荡主要是由于呼吸持续时间的振荡。多元线性回归和逻辑回归显示，心率下降主要与呼吸暂停持续时间相关，其次与潜在呼吸模式的特征相关。
In our previous study of 14 premature infants, apnea occurred at the minimum phase of ventilatory oscillations. The apneas corresponded to cessation of airflow at the nose and mouth and were not distinguished as central, mixed, or obstructive. Changes in heart rate associated with the apneas were not identified. To determine whether ventilatory pattern characteristics might predict either the type of apnea or heart rate changes during the apnea, we analyzed measurements of chest wall movement and heart rate that were made during the earlier studies. Chest wall movement measured by magnetometers was compared with airflow measured with a face mask and pneumotachograph. Tidal volume, breath duration, and ventilation were calculated on a breath-by-breath basis, converted to time-axis data strings, and filtered with a comb of zero phase shift digital band-pass filters to detect breathing patterns. Of 182 apneas greater than or equal to 3 s duration, 55% were central, 31% were mixed, and 14% were obstructive. All three types of apnea were related to ventilatory oscillations. Multiple linear and logistic regressions showed that an apnea was more likely to be obstructive when it was long and when the underlying ventilatory oscillation was due primarily to an oscillation in breath duration. Multiple linear and logistic regressions showed that decreases in heart rate were related primarily to the duration of apnea and secondarily to the characteristics of the underlying breathing patterns.