Familial aggregation of Parkinson's disease may affect progression of motor symptoms and dementia
Familial aggregation of Parkinson's disease may affect progression of motor symptoms and dementia
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DOI：
10.1002/mds.26856
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发表时间：
2017-02-01
影响因子：
8.6
通讯作者：
Tysnes, Ole-Bjorn
中科院分区：
文献类型：
--
作者：
Gaare, Johannes Jernqvist;Skeie, Geir Olve;Tysnes, Ole-Bjorn
家族聚集性在早发和晚发的帕金森病中都有描述，但还没有在真正的基于人群的样本中进行研究。本研究的目的是在基于人群的队列中确定特发性帕金森病的家族聚集性，并研究其与临床表型和疾病进展的关系。方法我们研究了挪威帕克韦斯特研究的家族史数据，这是一个具有良好特征的、基于人群的帕金森病发病队列和年龄匹配的健康对照。结果与对照组相比，使用扩展问卷时，帕金森病患者发生一级亲属关系的相对危险度增加(相对危险度=1.988；P=0.036)，而使用简化问卷时(相对危险度=1.453；P=0.224)。发病年龄和运动亚型差异无统计学意义(P=0.801)。然而，有帕金森病家族史的患者在UPDRS II中测量的7年内进展较慢(P=0.008)，MMSE下降幅度较小(P=0.046)。结论我们的研究结果证实了特发性帕金森病患者的家族聚集性。此外，我们还表明，帕金森病患者的阳性家族史与帕金森病症状进展较慢和认知能力下降有关。(C)2016国际帕金森病和运动障碍协会
BackgroundFamilial aggregation has been described in PD of both early and late onset, but has not been studied in a true population-based sample. Moreover, little is known about its association with disease progression and endophenotypes.ObjectivesThe objectives of this work were to determine familial aggregation of idiopathic PD in a population-based cohort and study the association with clinical endophenotypes and disease progression.MethodsWe examined family history data from the Norwegian ParkWest study, a well-characterized, population-based cohort of incident PD patients and age-matched healthy controls. Family data were collected at baseline with a simplified questionnaire (192 cases and 193 controls) and after 3 years of longitudinal follow-up using an extended questionnaire (172 cases and 171 controls).ResultsCompared to the controls, the PD patients had an increased relative risk of having a first-degree relative with PD when using the extended questionnaire (relative risk = 1.988; P = 0.036), but not when using the simplified questionnaire (relative risk = 1.453; P = 0.224). There was no significant difference in age of onset or motor subtype (P = 0.801). However, cases with a family history of PD had reduced progression over 7 years as measured by UPDRS II (P = 0.008) and smaller rate of decrease of MMSE (P = 0.046).ConclusionsOur findings confirm familial aggregation in a population-based cohort of idiopathic PD. Moreover, we show that positive family history of PD in patients is associated with a slower progression of PD symptoms and cognitive decline. (c) 2016 International Parkinson and Movement Disorder Society