Calcium and vitamin D in sarcoidosis: how to assess and manage.
Calcium and vitamin D in sarcoidosis: how to assess and manage.
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DOI：
10.1055/s-0030-1262215
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发表时间：
2010-08
影响因子：
3.2
通讯作者：
Rao DS
中科院分区：
文献类型：
--
作者：
Burke RR;Rybicki BA;Rao DS
结节病的肉芽肿性炎症改变了维生素D的合成，导致1，25-二羟维生素D的产生增加。越来越多的证据表明，维生素D是一种免疫调节激素，抑制先天免疫系统细胞的抗原呈递，以及Th 1细胞的细胞因子释放和增殖。这些和其他额外的健康益处导致普通人群中维生素D评估和药物补充的增加。这篇综述强调了维生素D的合成和一般免疫调节特性的改变，特别强调了已知的与结节病的相互作用。此外，评估维生素D营养状况，其药物补充，并与结节病患者的骨骼健康的管理进行审查。
The synthesis of vitamin D is altered by the granulomatous inflammation of sarcoidosis leading to increased production of 1, 25-dihydroxyvitamin D. Mounting evidence suggests that vitamin D is an immunomodulating hormone that inhibits both antigen presentation by cells of the innate immune system, and the cytokine release and proliferation of Th1 cells. These and other extraskeletal health benefits have led to an increase in vitamin D assessment and pharmacological supplementation in the general population. This review highlights the altered synthesis and general immunomodulating properties of vitamin D with a special emphasis on known interactions with sarcoidosis. In addition, the assessment of vitamin D nutritional status, its pharmacological supplementation, and the management of bone health in patients with sarcoidosis are reviewed.