Unexpectedly Stable Artificial Duplex from Flexible Acyclic Threoninol
Unexpectedly Stable Artificial Duplex from Flexible Acyclic Threoninol
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DOI：
10.1021/ja105539u
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发表时间：
2010-10-27
影响因子：
15
通讯作者：
Kashida, Hiromu
中科院分区：
文献类型：
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作者：
Asanuma, Hiroyuki;Toda, Takasuke;Kashida, Hiromu
通过将每个遗传核碱基A、G、C和T连接到D-苏氨醇分子上，然后将其作为结构单元掺入带有磷酸二酯键的支架中，合成了一种新的折叠体，无环苏氨醇核酸（aTNA）。我们发现，与其完全互补的链以反平行的方式，aTNA寡聚体形成一个非常稳定的双链体，比相应的DNA或RNA双链体更稳定，即使单链aTNA是相当灵活的，因此不采取预先组织的结构。
A new foldamer, acyclic threoninol nucleic acid (aTNA), has been synthesized by tethering each of the genetic nucleobases A, G, C, and T to D- threoninol molecules, which were then incorporated as building blocks into a scaffold bearing phosphodiester linkages. We found that with its fully complementary strand in an antiparallel fashion, the aTNA oligomer forms an exceptionally stable duplex that is far more stable than corresponding DNA or RNA duplexes, even though single-stranded aTNA is rather flexible and thus does not take a preorganized structure.