Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer
Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer
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DOI：
10.1159/000486367
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发表时间：
2018-01-01
影响因子：
4.7
通讯作者：
Rivera, Juan
中科院分区：
文献类型：
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作者：
Babli, Saleha;Payne, Richard J.;Rivera, Juan
背景资料：慢性淋巴细胞性甲状腺炎（CLT）对甲状腺乳头状癌（PTC）的表现和预后的影响一直是一个有争议的话题。目的：探讨CLT对PTC临床病理特征的影响。设计：回顾性研究。患者：纳入了2006年至2011年期间由2名合作研究者（Juan里维拉和Richard J. Payne）随访的所有PTC患者。结果如下：CLT存在于35%（166）的纳入患者中，与仅PTC组相比，CLT与TNM I期患者比例较高（p = 0.027）和持续性疾病患者较少（p = 0.014）相关。基于年龄（45岁）的数据分析< 45 or >显示，在老年组中，CLT的存在与持续性疾病（p = 0.03）和包膜浸润（p = 0.05）的患者较少相关。然而，在年龄< 45岁的患者中，与单纯PTC组相比，CLT的存在与更多的包膜浸润（p = 0.003）和甲状腺外延伸（p = 0.004）相关。结论：PTC患者的CLT与疾病分期较低相关，并且在>45岁的患者中疾病持续时间较短。患者
Background: The effects of chronic lymphocytic thyroiditis (CLT) on the presentation and outcome of papillary thyroid carcinoma (PTC) have long been a topic of controversy. Objective: To evaluate the effect of coexistent CLT on the clinicopathological features of PTC. Design: Retrospective study. Patients: All patients with PTC who had been followed by the 2 co-investigators (Juan Rivera and Richard J. Payne) between 2006 and 2011 were included. Results: CLT was present in 35% (166) of the included patients and was associated with a higher proportion of patients with TNM stage I (p = 0.027) and fewer patients with persistent disease (p = 0.014) in comparison with the PTC-only group. Analysis of the data based on age (< 45 or > 45 years) revealed that in the older group, the presence of CLT was associated with fewer patients with persistent disease (p = 0.03) and capsular invasion (p = 0.05). However, in patients < 45 years of age, the presence of CLT was associated with more capsular invasion (p = 0.003) and extrathyroidal extension (p = 0.004) compared with the PTC-only group. Conclusions: CLT in patients with PTC was associated with lower-stage disease and less disease persistence in patients >45 years of age. In patients