Breast-conserving therapy for centrally located breast cancer
Breast-conserving therapy for centrally located breast cancer
复制标题
DOI：
10.1097/sla.0b013e31815b6991
复制
发表时间：
2008-03-01
影响因子：
9
通讯作者：
Gnant, Michael
中科院分区：
文献类型：
--
作者：
Fitzal, Florian;Mittlboeck, Martina;Gnant, Michael
目的：分析保乳治疗（BCT）是否是一种肿瘤学安全的方法，并在中心型乳腺癌（CLBC）患者中获得良好的美容效果。背景资料：只有动力不足的回顾性单臂研究表明，对CLB进行肿瘤整形BCT可能是肿瘤学安全的，并可能获得良好的美容效果。作者回顾性分析了1485例接受BCT的乳腺癌患者的总体生存率和无复发生存率，比较了CLBC与非CLBC。此外，作者描述了4种不同的肿瘤整形技术用于CLBC患者的BCT，并根据最近制定的客观美容评估系统乳房对称指数将美容结果与简单的乳房肿块切除术进行了比较。Kaplan-Meier曲线显示5年总体、局部、或BCT后CLBC和非CLBC患者之间的无远处复发生存率（94% vs. 96%; 100% vs. 98%; 92% vs. 90%;中位随访期，35.3个月）。与单纯肿块切除术相比，肿瘤成形术BCT的美容效果差异显著（乳房对称指数：22 +/- 6%d vs. 44 +/- 12%d; P < 0.05）。结论：结果表明，CLBC的BCT在肿瘤学上是安全的，肿瘤成形术技术可改善美容效果。
Objective: To analyze whether breast-conserving therapy (BCT) may be an oncologically safe approach and result in a good cosmesis in patients with centrally located breast cancer (CLBC).Summary Background Data: Only underpowered, retrospective single-arm studies have suggested that oncoplastic BCT for CLB may be oncologically safe and may result in a good cosmesis.Methods: The authors retrospectively analyzed the overall and recurrence-free survival in 1485 patients with breast cancer undergoing BCT comparing CLBC with non-CLBC. Moreover, the authors described 4 different oncoplastic techniques for BCT in patients with CLBC and compared the cosmetic results with simple lumpectomy according to a recently elaborated objective cosmetic evaluation system, the Breast Symmetry Index.Results: Kaplan-Meier curves show no significant difference in a 5-year overall, local, or distant recurrence-free survival between patients with CLBC and non-CLBC after BCT (94% vs. 96%; 100% vs. 98%; 92% vs. 90%; median follow-up, 35.3 months). The cosmetic outcome after oncoplastic BCT compared with simple lumpectomy differed significantly (Breast Symmetry Index: 22 +/- 6%d vs. 44 +/- 12%d; P < 0.05).Conclusions: The results demonstrate that BCT for CLBC is oncologically safe and that oncoplastic techniques improve cosmesis.