Interstrain variation in murine aerobic capacity
Interstrain variation in murine aerobic capacity
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DOI：
10.1097/00005768-200112000-00012
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发表时间：
2001-12-01
期刊：
影响因子：
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通讯作者：
Kleeberger, SR
中科院分区：
文献类型：
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作者：
Lightfoot, JT;Turner, MJ;Kleeberger, SR
目的：遗传因素对有氧能力的影响尚不清楚。本研究的目的是测量近交系小鼠之间的最大有氧运动能力，以提供基本的遗传力估计。方法：8只8 - 10周龄的雌性小鼠，来自10个近交系（A/J，AKR/J，Balb/cJ，（CH）-H-3/HeJ，C57 B1/6 J，C57 L/J，C（3）Heb/FeJ，CBA/J，DBA/2 J和SWR/J），在跑步机上跑步直到耗尽。该方案从22 m.min（-1）开始，每4 min增加约6 m.min（-1）的速度。4 min后达到42.4 m.min（-1），此后每4 min增加2%的等级，直到小鼠无法脱离电击g-rid（150 V; 1.5 mA）。结果：近交系间最大运动持续时间差异有显著性（P < 0.0001）。各品系运动持续时间的顺序为Balb/cJ > SWR/J > CBA/J > C57 L/J >（CH）-H-3/HeJ > C（3）Heb/FeJ > C57 B1/6 J> AKR/J > DBA/2 J> A/J。广义遗传力的两个指标，组内相关（0.73）和遗传决定系数（0.58）均达到显著水平。结论：这些数据表明小鼠有氧能力有很强的遗传贡献。
Purpose: The contribution of genetic factors to aerobic capacity is unknown. The purpose of this study was to measure maximal aerobic performance among inbred strains of mice to provide basic heritability estimates, Methods: Eight female mice, 8 to 10 wk old, in 10 inbred strains (A/J, AKR/J, Balb/cJ, (CH)-H-3/HeJ, C57B1/6J, C57L/J, C(3)Heb/FeJ, CBA/J, DBA/2J, and SWR/J) were run on a treadmill until exhaustion. The protocol started at 22 m.min(-1) and increased in speed approximately 6 m.min(-1) every 4 min. After 4 min at 42.4 m.min(-1), the grade was increased 2% every 4 min thereafter until the mouse could not run off of the shock g-rid (150 V; 1.5 mA). Results: There were significant differences between inbred strains in maximal duration of exercise accomplished (P < 0.0001). The order of strain-specific exercise duration was Balb/cJ > SWR/J > CBA/J > C57L/J > (CH)-H-3/HeJ > C(3)Heb/FeJ > C57B1/6J > AKR/J > DBA/2J > A/J. Two measures of heritability in the broad sense, intraclass correlation (0.73), and the coefficient of genetic determination (0.58) were both significant. Conclusion: These data indicate that there is a strong genetic contribution to aerobic capacity in mice.