Bioactive guaianolides from siyekucai (Ixeris chinensis).
Bioactive guaianolides from siyekucai (Ixeris chinensis).
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DOI：
10.1021/np068015j
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发表时间：
2006-10
影响因子：
5.1
通讯作者：
Shu-jun Zhang;Ming Zhao;L. Bai;Toshiaki Hasegawa;Jin-lan Wang;Liyan Wang;Hongyan Xue;Qi-gang Deng;F. Xing;Yuhua Bai;J. Sakai;Jiao Bai;R. Koyanagi;Yoshinori Tsukumo;T. Kataoka;K. Nagai;K. Hirose;M. Ando
中科院分区：
文献类型：
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作者：
Shu-jun Zhang;Ming Zhao;L. Bai;Toshiaki Hasegawa;Jin-lan Wang;Liyan Wang;Hongyan Xue;Qi-gang Deng;F. Xing;Yuhua Bai;J. Sakai;Jiao Bai;R. Koyanagi;Yoshinori Tsukumo;T. Kataoka;K. Nagai;K. Hirose;M. Ando
从苦碟子中分得两个新的愈创木内酯，命名为苦碟子内酯D（5）和苦碟子内酯E（6），经结构鉴定分别为10 α-羟基-3-氧代愈创木-11（13）-烯-12，6 α-内酯（5）和10 α-羟基-3 β-O-[2，6-二（对羟基苯乙酰基）-β-葡萄糖基]愈创木-4（15），11（13）-二烯-12，6 α-内酯（6）。本文还报道了（11 S）-10 α-羟基-3-氧代愈创木基-4-烯-12，6 α-内酯（4）的首次分离和结构鉴定。知母皂苷E（6）对VA-13肺癌细胞具有明显的生长抑制作用（IC_（50）= 0.72 μ M）。
Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and their structures were determined to be 10alpha-hydroxy-3-oxoguaia-11(13)-eno-12,6alpha-lactone (5) and 10alpha-hydroxy-3beta-O-[2,6-di(p-hydroxyphenylacetyl)-beta-glucopylanosyl]guaia-4(15),11(13)-dieno-12,6alpha-lactone (6). The first isolation of (11S)-10alpha-hydroxy-3-oxoguaia-4-eno-12,6alpha-lactone (4) from natural sources and its characterization are also reported. Chinenciolide E (6) showed significant growth inhibitory activity toward VA-13 malignant lung tumor cells (IC50 = 0.72 microM).