Potential strategies and biosafety protocols used for dual-use research on highly pathogenic influenza viruses.
Potential strategies and biosafety protocols used for dual-use research on highly pathogenic influenza viruses.
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DOI：
10.1002/rmv.1729
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发表时间：
2012-11
影响因子：
11.1
通讯作者：
Jiang, Shibo
中科院分区：
文献类型：
--
作者：
Du, Lanying;Li, Ye;Gao, Jimin;Zhou, Yusen;Jiang, Shibo
Influenza A viruses (IAVs), particularly the highly pathogenic avian influenza (HPAI) H5N1, have posed a substantial threat to public health worldwide. Although the laboratory generation of the mutant influenza virus H5N1 with airborne transmissibility among mammals, which has been considered as a dual-use research, may benefit the development of effective vaccines and therapeutics against the emerging infectious agents, it may also pose threats to national biosecurity, laboratory biosafety, and/or public health. This review introduces the classification and characterization of IAVs, pinpoints historic pandemics and epidemics caused by IAVs, emphasizes the significance and necessity of biosafety, summarizes currently established biosafety-related protocols for IAV research, and provides potential strategies to improve biosafety protocols for dual-use research on the highly pathogenic avian influenza viruses and other emerging infectious agents.
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影响因子：
64.8
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Heymann DL
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