Clinical characteristics of infections caused by Mycoplasma pneumoniae P1 genotypes in children
Clinical characteristics of infections caused by Mycoplasma pneumoniae P1 genotypes in children
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DOI：
10.1007/s10096-018-3243-5
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发表时间：
2018-07-01
影响因子：
4.5
通讯作者：
Kese, Darja
中科院分区：
文献类型：
--
作者：
Berlot, Jasna Rodman;Krivec, Uros;Kese, Darja
肺炎支原体（M.根据P1粘附蛋白基因的DNA序列，肺炎链球菌分离株可分为两个主要的遗传组，P1 1型（MP1）和P1 2型（MP2）。本研究的目的是确定M. pneumoniae P1基因型与急性肺炎支原体感染的临床表现及严重程度相关。肺炎感染。我们比较了感染MP1或MP2的儿童的流行病学和临床数据。此外，我们分别分析了表现为M的个体表现的患者的数据。肺炎感染。对356例MP1感染者和126例MP2感染者的资料进行比较。MP2感染的儿童表现出较高的基线C反应蛋白水平中位数，并且更频繁地入院。P1基因型在不同临床表现的M患者中的分布不同。肺炎感染。在神经系统和心血管系统表现的患者中，MP2比MP1更常见，而MP1在其他表现中更常见。从我们的大队列的结果表明，这两个P1亚型可能有不同的致病潜力，与MP2菌株的感染可能比与MP1菌株的毒力更强。
Mycoplasma pneumoniae (M. pneumoniae) isolates can be classified into two major genetic groups, P1 type 1 (MP1) and P1 type 2 (MP2), based on the DNA sequence of the P1 adhesion protein gene. The aim of our study was to determine if M. pneumoniae P1 genotype is associated with disease manifestation and severity of acute M. pneumoniae infection. We compared epidemiological and clinical data of children infected with either MP1 or MP2. In addition, we separately analysed data of patients presenting with individual manifestations of M. pneumoniae infection. Data of 356 patients infected with MP1 were compared with those of 126 patients infected with MP2. MP2-infected children presented with higher median baseline C-reactive protein levels and were admitted to the hospital more often. The distribution of P1 genotype varied among groups of patients with different manifestations of M. pneumoniae infection. MP2 was more common than MP1 among patients with neurological and cardiovascular manifestations, whereas MP1 was more prevalent in other manifestations. The results from our large cohort indicate that the two P1 subtypes may have different pathogenic potential and that infections with MP2 strains could be more virulent than those with MP1 strains.