An integrated physical map covering 25 cM of human chromosome 8.

An integrated physical map covering 25 cM of human chromosome 8.
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覆盖人​​类 8 号染色体 25 cM 的综合物理图。

DOI:
10.1006/geno.1996.0084
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发表时间:
1996
期刊:
Genomics.
影响因子:
--
通讯作者:
Wells,DE
Wells,DE
中科院分区:
--
文献类型:
--
作者:
Chen,W;Hou,J;Wagner,MJ;Wells,DE

文献摘要

被引文献

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基于体细胞杂种和YAC重叠群的STS含量分析,我们建立了一个完整的人类染色体8 q23-q24.1物理图谱。在使用的63个STS中,有来自多个遗传图谱的标记和几个以前未绘制的多态性,从而将来自不同来源的遗传标记整合到基于其在物理图谱中的位置的全面的有序集合中。这些图谱将有助于分离导致人类遗传性疾病的基因,这些基因映射到这些染色体区域。
We have developed an integrated physical map for human chromosome 8q23–q24.1 based on STS content analysis of somatic cell hybrids and YAC contigs. Among the 63 STSs used are markers from multiple genetic maps and several previously unmapped polymorphisms, thus integrating genetic markers from different sources into comprehensive, ordered sets based on their positions in the physical map. These maps will facilitate the isolation of genes causing human inherited diseases that map to these chromosomal regions.