The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus
The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus
复制标题
蒙古沙鼠5分钟缺血的影响：II．
作者：
R. Suzuki;T. Yamaguchi;Choh‐Luh Li;I. Klatzo
实验记录了沙鼠在双侧夹持颈总动脉缺血5 min时和缺血5 min后大脑皮层和海马CA1区自发神经元活动。结果发现，皮质神经元和CA1神经元的自发活动在缺血后60 s内停止，在再循环后10-20 min开始重新出现。在接下来的24小时内，大多数记录的CA1神经元表现出过度活跃。这主要是通过峰值放电的增加来证明的，而大脑皮层的记录在咬合前的范围内。缺血后第2天，CA1神经元未见功能，处于功能性死亡状态，但此时组织切片显示其细胞结构基本保留。
SummarySpontaneous neuronal activity was recorded in the cerebral cortex and the CA1 sector of the hippocampus in gerbils during and after 5-min ischemia, produced by bilateral clamping of the common carotid arteries. It was found that spontaneous activity in both cortical and CA1 neurons ceased within 60 s after the onset of ischemia and that it began to reappear 10–20 min after the recirculation. During the next 24 h most CA1 neurons which were recorded showed hyperactivity. This was evident primarily by an increase in spike discharges, whereas recordings from the cerebral cortex were within the preocclusion ranges. On the 2nd day after ischemia, functioning CA1 neurons could not be found, as if they were in a state of functional death, although histological sections showed a general preservation of their cellular structure at that time.