Moving toward a generalizable application of central thalamic deep brain stimulation for support of forebrain arousal regulation in the severely injured brain
Moving toward a generalizable application of central thalamic deep brain stimulation for support of forebrain arousal regulation in the severely injured brain
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DOI：
10.1111/j.1749-6632.2012.06712.x
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Schiff, Nicholas D.
中科院分区：
文献类型：
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作者：
Schiff, Nicholas D.
这篇综述考虑了未来的挑战，为开发一个可推广的战略，使用中央丘脑深部脑刺激（CT/DBS），以支持唤醒调节机制，在严重受伤的大脑。将CT/DBS应用于严重脑损伤患者的历史努力和单一受试者研究的概念验证结果进行了讨论。意识恢复的电路和细胞机制被认为与CT/DBS的应用相关，以改善非进行性脑损伤的意识和认知。最后，发展方向，并测试CT/DBS的可推广标准的建议，其目的是确定神经元基板和行为概况，可能会最好地受益于觉醒调节机制的支持。
This review considers the challenges ahead for developing a generalizable strategy for the use of central thalamic deep brain stimulation (CT/DBS) to support arousal regulation mechanisms in the severely injured brain. Historical efforts to apply CT/DBS to patients with severe brain injuries and a proof-of-concept result from a single-subject study are discussed. Circuit and cellular mechanisms underlying the recovery of consciousness are considered for their relevance to the application of CT/DBS, to improve consciousness and cognition in nonprogressive brain injuries. Finally, directions for development, and testing of generalizable criteria for CT/DBS are suggested, which aim to identify neuronal substrates and behavioral profiles that may optimally benefit from support of arousal regulation mechanisms.