Multiple Timescales of Memory in Lateral Habenula and Dopamine Neurons
Multiple Timescales of Memory in Lateral Habenula and Dopamine Neurons
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DOI：
10.1016/j.neuron.2010.06.031
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发表时间：
2010-08-12
期刊：
影响因子：
16.2
通讯作者：
Hikosaka, Okihide
中科院分区：
文献类型：
--
作者：
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide
中脑多巴胺神经元被认为是基于对过去奖励经验的记忆来预测未来奖励的信号。人们对他们的奖励记忆的来源以及控制其时间尺度的因素知之甚少。在这里，我们记录了多巴胺神经元，以及它们的输入来源之一，外侧缰，而动物则根据过去的奖励历史预测即将到来的奖励。我们发现，外侧缰核和多巴胺神经元获得两种不同的奖励记忆：在任务开始时表达的短时间尺度记忆和在未来奖励结果被揭示时表达的接近最佳的长时间尺度记忆。短期和长期的记忆表现为不同形式的奖励导向的眼球运动。我们的数据表明，缰核-多巴胺通路包含多个记忆时间尺度，并为它们在动机行为中的作用提供了证据。
Midbrain dopamine neurons are thought to signal predictions about future rewards based on the memory of past rewarding experience. Little is known about the source of their reward memory and the factors that control its timescale. Here we recorded from dopamine neurons, as well as one of their sources of input, the lateral habenula, while animals predicted upcoming rewards based on the past reward history. We found that lateral habenula and dopamine neurons accessed two distinct reward memories: a short-timescale memory expressed at the start of the task and a near-optimal long-timescale memory expressed when a future reward outcome was revealed. The short- and long-timescale memories were expressed in different forms of reward-oriented eye movements. Our data show that the habenula-dopamine pathway contains multiple timescales of memory and provide evidence for their role in motivated behavior.