Association between a functional polymorphism in the renin-angiotensin system and completed suicide
Association between a functional polymorphism in the renin-angiotensin system and completed suicide
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DOI：
10.1007/s00702-006-0483-9
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发表时间：
2006-12-01
影响因子：
3.3
通讯作者：
Maeda, K.
中科院分区：
文献类型：
--
作者：
Hishimoto, A.;Shirakawa, O.;Maeda, K.
有人认为自杀与应激反应系统紊乱有关，并且与遗传有关。肾素-血管紧张素系统 (RAS) 已被证明会影响应激反应，并且 RAS 相关基因中的几种功能多态性预计会改变蛋白质功能。我们假设 RAS 失调与自杀有关，并检查了自杀完成与 RAS 相关基因的四种功能多态性之间的关联：血管紧张素原 M235T、血管紧张素转换酶 (ACE) 插入 (l)/缺失 (D)、血管紧张素 1 型受体 A1166C 和 G-蛋白-β 3 C825T 基因多态性。 ACE I/D 多态性的 I 等位基因被发现在自杀事件中比对照组更常见 (P=0.014)。还发现 I 等位基因在男性自杀中的频率高于男性对照组（P=0.022），而女性中则不然。这些结果表明，基因多态性引起的RAS功能改变与男性自杀易感性有关。
Suicide has been suggested to involve disturbances in the stress response system and to be related to genetics. The renin-angiotensin system (RAS) has been shown to affect the stress response, and several functional polymorphisms in RAS-related genes have been predicted to alter protein function. We hypothesized that the dysregulation of RAS was involved in suicide, and examined the association between completed suicides and four functional polymorphisms of RAS-related genes: the angiotensmogen M235T, angiotensin-converting enzyme (ACE) insertion(l)/deletion(D), angiotensin type-1 receptor A1166C, and G-protein-beta 3 C825T gene polymorphisms. The I allele of the ACE I/D polymorphism was found to be more frequent in completed suicides than in controls (P=0.014). The I allele was also found to be more frequent in male completed suicides (P=0.022) than in male controls, while this was not the case in females. These results suggest that the alteration of RAS function caused by the genetic polymorphism is involved in the susceptibility to suicide in males.