Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats
Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats
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DOI：
10.3177/jnsv.55.252
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发表时间：
2009-06-01
影响因子：
1.6
通讯作者：
Yanagita, Teruyoshi
中科院分区：
文献类型：
--
作者：
Ikeda, Ikuo;Kudo, Mariko;Yanagita, Teruyoshi
与酪蛋白（CAS）相比，大豆分离蛋白（SPI）及其未消化的高分子组分（HMF）经蛋白酶彻底消化后，可显著降低大鼠血清和肝脏胆固醇浓度。喂食SPI和HMF的大鼠胆汁胆固醇排泄量显著高于喂食CAS的大鼠。SPI和I-IMF组大鼠肝脏ATP结合盒转运体G5（ABCG 5）和ATP结合盒转运体G8（ABCG 8）mRNA的表达显著高于CAS组。这些观察结果表明，SPI和HMF组胆固醇的胆汁排泄增加是由Abcg 5/Abcg 8的表达增强引起的。
Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS. Hepatic expression of ATP-binding cassette transporter G5 (ABCG5) and ATP-binding cassette transporter G8 (ABCG8) mRNA was significantly higher in rats fed SPI and I-IMF than in those fed CAS. These observations suggest that increased biliary excretion of cholesterol in SPI and HMF groups is caused by the enhanced expression of Abcg5/Abcg8.