Immune phenomena in glaucoma and conformational disorders: why is the second eye not involved?

Immune phenomena in glaucoma and conformational disorders: why is the second eye not involved?
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DOI:
10.1097/ijg.0000000000000115
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发表时间:
2014-10-01
影响因子:
2
通讯作者:
Kuehn, Markus H
Kuehn, Markus H
中科院分区:
医学3区
文献类型:
--
作者:
Kuehn, Markus H

文献摘要

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Data along several lines of evidence have suggested that a systemic autoimmune response may be provoked in glaucoma and could contribute to retinal ganglion cell loss. If such an autoimmune response exists, one could predict that in cases of unilateral glaucoma, autoantibodies generated would affect both eyes, leading to damage in the unaffected, contralateral eye in an intraocular pressure-independent manner. However, such an effect has not yet been reported. There are currently no data to reconcile these contrasting observations but a review of the literature suggests a possible explanation.