Persistent arthralgia associated with chikungunya virus: A study of 88 adult patients on Reunion Island
Persistent arthralgia associated with chikungunya virus: A study of 88 adult patients on Reunion Island
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DOI：
10.1086/590003
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发表时间：
2008-08-15
影响因子：
11.8
通讯作者：
Paganin, Fabrice
中科院分区：
文献类型：
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作者：
Borgherini, Gianandrea;Poubeau, Patrice;Paganin, Fabrice
背景。2005-2006年期间，留尼汪岛爆发了基孔肯雅病毒感染。基孔肯雅病毒感染后的持续性关节痛已有报道，但治疗这方面疾病的研究很少。2005-2006年期间转诊到留尼汪南方医院集团的经实验室确诊的急性基孔肯雅病毒感染的成年患者被要求参加这项研究。在急性疾病发生后平均18个月对患者进行评估。评估包括在标准表格上回答问题，进行医学检查，并检测是否存在基孔肯雅病毒的IgM抗体。共纳入88例患者，平均年龄58.3岁，男女比例为1.1:1.0。58例（65.9%）患者曾因急性基孔肯雅病毒感染住院，39例（44%）患者报告感染基孔肯雅病毒前有关节痛史。56名患者（63.6%）报告与基孔肯雅病毒感染有关的持续性关节痛，近一半患者的关节疼痛对日常活动产生负面影响。所有病例均为多关节性关节痛，31例（55.4%）患者持续疼痛。总体而言，35例（39.7%）患者基孔肯雅病毒IgM抗体检测结果阳性。持续性和致残性关节痛是这组与18个月前经历过严重基孔肯雅病毒感染的患者经常关注的问题。需要进一步的研究来评估一般人群中持续性关节痛的患病率，以确定该疾病的真正负担。
Background. An outbreak of chikungunya virus infection occurred on Reunion Island during the period 2005-2006. Persistent arthralgia after chikungunya virus infection has been reported, but few studies have treated this aspect of the disease.Methods. Adult patients with laboratory-confirmed acute chikungunya virus infection who were referred to Groupe Hospitalier Sud Reunion during the period 2005-2006 were asked to participate in the study. Patients were assessed a mean of 18 months after acute disease occurred. Assessment consisted of answering questions on a standard form, undergoing a medical examination, and being tested for the presence of IgM antibodies to chikungunya virus.Results. Eighty-eight patients (mean age, 58.3 years; male-to-female ratio, 1.1:1.0) were included in this study. Fifty-eight patients (65.9%) had been hospitalized for acute chikungunya virus infection, and a history of arthralgia before chikungunya virus infection was reported by 39 patients (44%). Fifty-six patients (63.6%) reported persistent arthralgia related to chikungunya virus infection, and in almost one-half of the patients, the joint pain had a negative impact on everyday activities. Arthralgia was polyarticular in all cases, and pain was continuous in 31 patients (55.4%). Overall, 35 patients (39.7%) had test results positive for IgM antibodies to chikungunya virus.Conclusions. Persistent and disabling arthralgia was a frequent concern in this cohort of patients who had experienced severe chikungunya virus infection similar to 18 months earlier. Further studies are needed to evaluate the prevalence of persistent arthralgia in the general population to determine the real burden of the disease.