Remotely triggered release from magnetic nanoparticles
Remotely triggered release from magnetic nanoparticles
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DOI：
10.1002/adma.200700091
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发表时间：
2007-11-19
影响因子：
29.4
通讯作者：
Bhatia, Sangeeta N.
中科院分区：
文献类型：
--
作者：
Derfus, Austin M.;von Maltzahn, Geoffrey;Bhatia, Sangeeta N.
多功能纳米粒子是多价的、远程驱动的、无创的成像。超顺磁性纳米粒子将外部电磁能量转化为热量，从而融化作为可调节的、热不稳定的纽带在体内释放模型药物的寡核苷酸双链(见图)。
Multifunctional nanoparticles are multivalent, remotely-actuated, and imaged non-invasively. Superparamagnetic nanoparticles transduce external electromagnetic energy to heat, thereby melting oligonucleotide duplexes that act as tunable, heat-labile tethers to release model drugs in vivo (see figure).