The Oxford Vegetarian Study: an overview
The Oxford Vegetarian Study: an overview
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DOI：
10.1093/ajcn/70.3.525s
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发表时间：
1999-09-01
影响因子：
7.1
通讯作者：
Key, TJA
中科院分区：
文献类型：
--
作者：
Appleby, PN;Thorogood, M;Key, TJA
牛津素食研究是一项前瞻性研究，在1980年至1984年期间在英国招募了6000名素食者和5000名非素食者作为对照。对研究数据的横断面分析显示，素食者的总胆固醇和低密度脂蛋白胆固醇浓度低于肉食者;素食者和食鱼者的值介于两者之间。男性和女性的肉类和奶酪摄入量与总胆固醇浓度呈正相关，膳食纤维摄入量与总胆固醇浓度呈负相关。经过12年的随访，整个队列的全因死亡率约为英格兰和威尔士人群的一半（标准化死亡率比，0.46; 95%CI，0.42，0.51）。在调整吸烟、体重指数和社会阶层后，对于研究的每个死亡终点，非肉食者的死亡率均低于肉食者[相对风险和95%CI：所有死因为0.80（0.65，0.99），缺血性心脏病为0.72（0.47，1.10），所有恶性肿瘤为0.61（0.44，0.84）]。缺血性心脏病的死亡率也与总动物脂肪、饱和动物脂肪和膳食胆固醇的估计摄入量呈正相关。其他分析表明，非肉食者需要紧急阑尾切除术的风险只有肉食者的一半，而英国的素食主义者可能有缺碘的风险。因此，在这项研究中，素食者的健康状况总体上是好的，并与非素食者的对照组相比。需要更大规模的研究来检查素食者中特定癌症和其他疾病的发病率。
The Oxford Vegetarian Study is a prospective study of 6000 vegetarians and 5000 nonvegetarian control subjects recruited in the United Kingdom between 1980 and 1984. Cross-sectional analyses of study data showed that vegans had lower total- and LDL-cholesterol concentrations than did meat eaters; vegetarians and fish eaters had intermediate and similar values. Meat and cheese consumption were positively associated, and dietary fiber intake was inversely associated, with total-cholesterol concentration in both men and women. After 12 y of follow-up, all-cause mortality in the whole cohort was roughly half that in the population of England and Wales (standardized mortality ratio, 0.46; 95% CI, 0.42, 0.51). After adjusting for smoking, body mass index, and social class, death rates were lower in non-meat-eaters than in meat eaters for each of the mortality end-points studied [relative risks and 95% CIs: 0.80 (0.65, 0.99) for all causes of death, 0.72 (0.47, 1.10) for ischemic heart disease, and 0.61 (0.44, 0.84) for all malignant neoplasms]. Mortality from ischemic heart disease was also positively associated with estimated intakes of total animal fat, saturated animal fat, and dietary cholesterol. Other analyses showed that non-meat-eaters had only half the risk of meat eaters of requiring an emergency appendectomy, and that vegans in Britain may be at risk for iodine deficiency. Thus, the health of vegetarians in this study is generally good and compares favorably with that of the nonvegetarian control subjects. Larger studies are needed to examine rates of specific cancers and other diseases among vegetarians.