Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses.
Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses.
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DOI：
10.1155/2012/752563
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发表时间：
2012
影响因子：
--
通讯作者：
Matsuda S
中科院分区：
文献类型：
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作者：
Kitagishi Y;Kobayashi M;Kikuta K;Matsuda S
几种作用于单胺神经传递的药理学制剂被用于精神疾病的治疗。PI3K/AKT和GSK3通路的调控可能是突触神经传递亚细胞整合的重要信号中枢。这些通路也调节神经元细胞的增殖、迁移和可塑性。有证据表明，神经元的炎症与抑郁症的病理有关。神经元的炎症激活导致神经胶质成分的丧失，这与抑郁症的病理特征一致。抗抑郁药物的抗炎反应机制已被发现与血红素氧化酶-1表达的增强有关。脑内的这种诱导在神经保护和神经可塑性中也很重要。由于参与细胞存活和神经可塑性的酶与神经营养因子失调有关，PI3K/AKT/GSK3可能为抑郁症的神经保护提供了重要的信号通路。本文就PI3K/AKT/GSK3通路参与精神疾病神经元细胞信号转导的研究进展进行综述。
Several pharmacological agents acting on monoamine neurotransmission are used for the management of mental illnesses. Regulation of PI3K/AKT and GSK3 pathways may constitute an important signaling center in the subcellular integration of the synaptic neurotransmission. The pathways also modulate neuronal cell proliferation, migration, and plasticity. There are evidences to suggest that inflammation of neuron contributes to the pathology of depression. Inflammatory activation of neuron contributes to the loss of glial elements, which are consistent with pathological findings characterizing the depression. A mechanism of anti-inflammatory reactions from antidepressant medications has been found to be associated with an enhancement of heme oxygenase-1 expression. This induction in brain is also important in neuroprotection and neuroplasticity. As enzymes involved in cell survival and neuroplasticity are relevant to neurotrophic factor dysregulation, the PI3K/AKT/GSK3 may provide an important signaling for the neuroprotection in depression. In this paper, we summarize advances on the involvement of the PI3K/AKT/GSK3 pathways in cell signaling of neuronal cells in mental illnesses.