GLUCOSE TOLERANCE AND TIME SEQUENCE OF ADIPOSITY, HYPERINSULINEMIA AND HYPERGLYCEMIA IN OBESE-HYPERGLYCEMIC MICE (OBOB)
GLUCOSE TOLERANCE AND TIME SEQUENCE OF ADIPOSITY, HYPERINSULINEMIA AND HYPERGLYCEMIA IN OBESE-HYPERGLYCEMIC MICE (OBOB)
复制标题
DOI：
10.1016/0026-0495(70)90065-x
复制
发表时间：
1970-01-01
期刊：
影响因子：
9.8
通讯作者：
BATT, RAL
中科院分区：
文献类型：
--
作者：
CHLOUVERAKIS, C;DADE, EF;BATT, RAL
通过胃管给予肥胖高血糖小鼠（obob）固定的、与体重无关的葡萄糖负荷（100毫克），引起的血糖反应几乎与瘦动物相同，但与体重成比例的葡萄糖负荷（5毫克/克）会引起明显且持续的高血糖。静脉注射加权剂量的葡萄糖（1 mg./Gm.）在肥胖和瘦动物中显示出相似的分布体积和清除率。考虑到肥胖动物的脂肪组织质量显着增大，其表面上正常的葡萄糖清除率异常低。根据对幼年动物（三周龄）进行的实验，表明可可豆中脂肪组织质量的增大先于血糖和血清胰岛素显着升高的发生。
A fixed, independent of body weight, load of glucose (100 mg.) given by stomach tube to obese-hyperglycemic mice(obob)caused a blood-glucose response almost identical to that of lean animals, but a glucose load proportional to body weight (5 mg./Gm.) provoked marked and sustained hyperglycemia. A weighted dose of glucose (1 mg./Gm.) given intravenously showed similar volumes of distribution and clearance rates in obese and lean animals. The apparently normal rate of glucose clearance of the obese animals is abnormally low considering the marked enlargement of their adipose tissue mass. On the basis of experiments performed on young animals (three weeks of age), it is suggested that the enlargement of adipose tissue mass in theobobprecedes the occurrence of significant elevations of blood glucose and serum insulin.