Chemical neurotoxicity: detection and analysis in organotypic cultures of sensory and motor systems.
Chemical neurotoxicity: detection and analysis in organotypic cultures of sensory and motor systems.
复制标题
化学神经毒性：感觉和运动系统器官型培养物的检测和分析。
DOI：
10.1016/0278-6915(86)90110-9
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
VandeWater,T
中科院分区：
文献类型：
--
作者：
Spencer,PS;Crain,SM;Bornstein,MB;Peterson,ER;VandeWater,T
筛选具有人类神经毒性（和治疗性）特性的化学物质可以借助由小鼠感觉和神经肌肉组织的胚胎外植体组成的器官型组织培养物进行，这些组织在体外发育，具有其特征的细胞结构和功能组织。支持这一说法的是大量的研究，这些研究描述了器官型神经培养中一系列特定的、化学诱导的反应，这些反应与人类和动物神经系统中诱导的变化相似。
Screening of chemical substances for human neurotoxic (and therapeutic) properties may be carried out with the aid of organotypic tissue cultures composed of foetal explants of mouse sensory and neuromuscular tissues that developin vitrotheir characteristic cytoarchitectural and functional organization. Supporting this statement is a wealth of studies describing a range of specific, chemically-induced responses in organotypic neural cultures that parallel changes induced in the nervous system of humans and animals.