Benzamil, a blocker of epithelial Na(+) channel-induced upregulation of artery oxygen pressure level in acute lung injury rabbit ventilated with high frequency oscillation.
Benzamil, a blocker of epithelial Na(+) channel-induced upregulation of artery oxygen pressure level in acute lung injury rabbit ventilated with high frequency oscillation.
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DOI：
10.1016/j.bbrc.2004.12.098
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发表时间：
2005-02
影响因子：
3.1
通讯作者：
Nobuko Taguchi;N. Niisato;Y. Sawabe;H. Miyazaki;Yasutomi Hirai;Y. Marunaka
中科院分区：
文献类型：
--
作者：
Nobuko Taguchi;N. Niisato;Y. Sawabe;H. Miyazaki;Yasutomi Hirai;Y. Marunaka
肺上皮细胞表达的上皮性Na+通道(ENaC)通过清除肺腔内积液，在急性肺损伤后肺水肿的恢复过程中起关键作用。肺水肿导致气体交换功能障碍，降低动脉血氧分压水平[公式：见正文]。为了研究ENaC是否在急性肺损伤中从下降水平恢复到正常水平起到关键作用，我们将ENaC的特异性阻滞剂苯扎米(20μM)应用于高频振荡呼吸机(HFOV)治疗的急性肺损伤患者的肺腔间隙。高频振荡呼吸机是一种肺保护性呼吸机，潮气量较小，压力波动比传统机械通气(CMV)小。在HFOV而不是CMV的急性损伤肺中，苯扎米促进了[公式：见文本]的恢复。提示在HFOV治疗急性肺损伤时，ENaC阻滞剂苯扎米可作为HFOV联合治疗急性肺损伤的药物。
The epithelial Na+transport via an epithelial Na+channel (ENaC) expressed in the lung epithelium would play a key role in recovery from lung edema at acute lung injury by removing the fluid in lung luminal space. The lung edema causes dysfunction of gas exchange, decreasing oxygen pressure level of artery [Formula: see text] . To study if ENaC plays a key role in recovering [Formula: see text] from a decreased level to a normal one in acute lung injury, we applied benzamil (20μM, a specific blocker of ENaC) to the lung luminal space in acute lung injury treated with high frequency oscillation ventilation (HFOV) that is a lung-protective ventilation with a lower tidal volume and a smaller pressure swing than conventional mechanical ventilation (CMV). Benzamil facilitated the recovery of [Formula: see text] in acutely injured lung with HFOV but not CMV. The observation suggests that in acutely injured lung treated with HFOV an ENaC blocker, benzamil, can be applied as a therapeutic drug for acute lung injury combing with HFOV.