Relationship Between Obstructive Sleep Apnea Severity and Brain Activation During a Sustained Attention Task
Relationship Between Obstructive Sleep Apnea Severity and Brain Activation During a Sustained Attention Task
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DOI：
10.1093/sleep/32.3.373
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发表时间：
2009-03-01
期刊：
影响因子：
5.6
通讯作者：
Drummond, Sean P. A.
中科院分区：
文献类型：
--
作者：
Ayalon, Liat;Ancoli-Israel, Sonia;Drummond, Sean P. A.
研究目的：本研究的目的是（1）表征认知和大脑相关的注意力和反应速度在阻塞性睡眠呼吸暂停（OSA）患者和（2）评估与OSA severity.Design措施的性能和大脑激活的关联：患者与OSA和控制进行了比较，在持续的注意力任务的性能和大脑激活。关联的反应时间和大脑激活与呼吸暂停低通气指数，夜间缺氧，觉醒进行了assessed.Setting：功能磁共振成像，而参与者进行了去不去的任务。的“去”试验的去不去task被用来索引attention processing.Participants：14例OSA患者和14名正常对照组受试者具有相同的年龄，体重指数，血压，和education.Interventions：N/A.Measurements和结果：OSA患者表现出减少大脑激活扣带回，额叶和顶叶区域通常参与注意力的任务，与对照组相比。在OSA患者中，唤醒指数增加，而非去饱和指数，与平均反应时间减慢以及唤醒和注意力、反应选择、运动反应和决策相关区域的大脑激活减少相关。呼吸暂停低通气指数，本身，是不相关的大脑responsibility.Conclusions的变化：OSA患者表现出减少大脑激活与对照组相比，在注意力任务。唤醒指数（但不是缺氧）与反应时间和大脑激活的关系表明，警觉性和反应时间与睡眠中断的测量比与缺氧的测量显示出更大的相关性。
Study Objectives: The objectives of this study were to (1) characterize cognitive and cerebral correlates of attention and response speed in patients with obstructive sleep apnea (OSA) and (2) assess the association of performance and brain activation with measures of OSA severity.Design: Patients with OSA and controls were compared on performance and brain activation during a sustained attention task. The association of reaction time and brain activation with apnea-hypopnea index, nocturnal hypoxia, and arousals was assessed.Setting: Functional magnetic resonance imaging was conducted while participants performed a Go-No-Go task. The 'Go' trials of the Go-No-Go task were used to index attention processing.Participants: Fourteen patients with OSA and 14 normal control subjects with equivalent age, body mass index, blood pressure, and education.Interventions: N/A.Measurements and Results: Patients with OSA showed decreased brain activation in cingulate, frontal, and parietal regions typically involved in attention tasks, compared with control subjects. Within the patients with OSA, increasing arousal index, but not desaturation index, was associated with slower mean reaction time and with decreased brain activation in areas involved in arousal and attention, response selection, motor response, and decision making. The apnea-hypopnea index, by itself, was not associated with changes in cerebral response.Conclusions: Patients with OSA showed decreased brain activation compared with control subjects during an attention task. The association of arousal index (but not hypoxia) with slow reaction times and brain activation suggests that alertness and reaction times show greater correlations with measures of sleep disruption than with measures of hypoxia.