An integrated map with cosmid/PAC contigs of a 4-Mb Down syndrome critical region.
An integrated map with cosmid/PAC contigs of a 4-Mb Down syndrome critical region.
复制标题
4-Mb 唐氏综合症关键区域的粘粒/PAC 重叠群的集成图谱。
作者：
K. Osoegawa;R. Susukida;S. Okano;J. Kudoh;S. Minoshima;N. Shimizu;P. D. de Jong;J. Groet;J. Ives;H. Lehrach;D. Nižetić;E. Soeda
The major phenotypic features of Down syndrome have been correlated with partial trisomies of chromosome 21, allowing us to define the candidate gene region to a 4-Mb segment on the 21q22.2 band. We present here a high-resolution physical map with megabase-sized cosmid/PAC contigs. This ordered clone library has provided unique material for the integration of a variety of mappable objects, including exons, cDNAs, restriction sites, etc. Furthermore, our results have exemplified a strategy for the completion of the chromosome 21 map to sequencing.
