Molecular Imaging of PARP
Molecular Imaging of PARP
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DOI：
10.2967/jnumed.117.189936
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发表时间：
2017-07-01
影响因子：
9.3
通讯作者：
Reiner, Thomas
中科院分区：
文献类型：
--
作者：
Carney, Brandon;Kossatz, Susanne;Reiner, Thomas
聚（腺苷二磷酸核糖）聚合酶（PARP）家族是细胞 DNA 损伤反应的重要因素，因其在许多疾病（尤其是癌症）中的作用而受到广泛关注。使用荧光或放射性标记标签对 PARP 进行靶向分子成像继治疗抑制剂的成功之后，在过去几年中获得了发展势头。本综述涵盖了从最初的显像剂到当前技术水平的 PARP 成像，重点关注这些试剂所实现的临床应用。
The poly(adenosine diphosphate-ribose) polymerase (PARP) family of enzymes is an important factor in the cellular DNA damage response and has gained much attention for its role in many diseases, particularly cancer. Targeted molecular imaging of PARP using fluorescent or radiolabeled tags has followed on the success of therapeutic inhibitors and gained momentum over the past few years. This review covers PARP imaging from the very first imaging agents up to the current state of the technology, with a focus on the clinical applications made possible by these agents.