Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: An fMRI study
Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: An fMRI study
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DOI：
10.1176/appi.neuropsych.19.3.274
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发表时间：
2007-06-01
影响因子：
2.9
通讯作者：
Lowe, Mark J.
中科院分区：
文献类型：
--
作者：
Anand, Amit;Li, Yu;Lowe, Mark J.
据推测，潮汐抑制剂的作用之一是增加皮质情绪调节区和边缘系统情绪产生区之间的功能连接。这种抗抑郁作用的一个后果被认为是减少了对负面情绪刺激的边缘系统激活。12名未经药物治疗的单相抑郁患者和11名密切匹配的健康对照受试者在基线和6周后完成了两次磁共振成像（MRI）扫描。抑郁症患者在两次治疗之间接受舍曲林治疗。在每次MRI会话期间，受试者完成静息状态功能连接扫描和常规块设计阴性与中性图片区域脑激活扫描。经过6周的舍曲林治疗静息状态下，ACC和边缘区域之间的功能连接增加，而边缘激活响应于消极与中性图片减少。本研究的结果与抗抑郁药治疗对皮质边缘功能连接和边缘系统响应情绪刺激的激活具有相互作用的假设一致。
It has been hypothesized that one of the effects of an tidepressants is to increase functional connectivity between the cortical mood-regulating and the limbic mood-generating regions. One consequence of this antidepressant effect is thought to be decreased limbic activation in response to negative emotional stimuli. Twelve unmedicated unipolar depressed patients and 11 closely matched healthy comparison subjects completed two magnetic resonance imaging MRI) scanning sessions at baseline and after 6 weeks. Depressed patients received treatment with sertraline between the two sessions. During each MRI session, subjects completed a resting state functional connectivity scan and a conventional block-design negative vs. neutral pictures regional brain activation scan. After 6 weeks of sertraline treatment resting state, functional connectivity between the ACC and limbic regions increased while limbic activation in response to negative versus neutral pictures decreased. The results of this study are consistent with the hypothesis that antidepressant treatment has reciprocal effects on corticolimbic functional connectivity and limbic activation in response to emotional stimuli.