Synthesis of imidazoles through the copper-catalyzed cross-cycloaddition between two different isocyanides
Synthesis of imidazoles through the copper-catalyzed cross-cycloaddition between two different isocyanides
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DOI：
10.1021/ja0617439
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发表时间：
2006-08-23
影响因子：
15
通讯作者：
Yamamoto, Yoshinori
中科院分区：
文献类型：
--
作者：
Kanazawa, Chikashi;Kamijo, Shin;Yamamoto, Yoshinori
铜催化的两种不同异氰化物之间的反应生成相应的杂芳构化产物，咪唑类化合物，产率很高。反应很可能是通过铜催化剂激活异氰化物中的Sp3c−H键，然后铜异氰化物中间体与芳基异氰酸酯之间的[3+2]环加成反应进行的。
The copper-catalyzed reaction between two different isocyanides produces the corresponding heteroaromatization products, imidazoles, in good yields. The reaction proceeds most probably through the activation of the sp3C−H bond in the isocyanides by a copper catalyst, followed by a [3 + 2] cycloaddition between the cuprioisocyanide intermediates and arylisocyanides.