Postoperative pancreatic fistula: An international study group (ISGPF) definition
Postoperative pancreatic fistula: An international study group (ISGPF) definition
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DOI：
10.1016/j.surg.2005.05.001
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发表时间：
2005-07-01
期刊：
影响因子：
3.8
通讯作者：
Buchler, M
中科院分区：
文献类型：
--
作者：
Bassi, C;Dervenis, C;Buchler, M
背景术后胰瘘（POPF）仍然被认为是一个主要的并发症。POPF的发生率在不同的报告中差异很大，这取决于每个手术中心应用的定义。我们的目标是商定一个客观和国际公认的定义，以允许比较不同的手术经验。一个国际胰腺外科专家小组，在知名的高容量中心工作，回顾了关于该主题的文献，并共同制定了一个简单、客观、可靠和易于应用的POPF定义，主要根据临床影响进行分级。POPF代表胰肠吻合口愈合/密封失败或与吻合口无直接关系的实质性渗漏。一个全面的定义是术后第3天或之后任何可测量的液体量的引流量，淀粉酶含量大于血清淀粉酶活性的3倍。根据对患者住院过程的临床影响，将POPF分为A、B、C三个等级。目前POPF的定义和临床分级应允许在未来的新技术，新操作，或新的药理学药物，可能会影响胰腺疾病的手术治疗时，手术经验的现实比较。
Background. Postoperative pancreatic fistula (POPF) is still regarded as a major complication. The incidence of POPF varies greatly in different reports, depending on the definition applied at each surgical center. OUT aim was to agree upon an objective and internationally accepted definition to allow comparison of different surgical experiences.Methods. An international panel of pancreatic surgeons, working in well-known, high-volume centers, reviewed the literature on the topic and worked together to develop a simple, objective, reliable, and easy-to-apply definition of POPF, graded primarily on clinical impact.Results. A POPF represents a failure of healing/sealing of a pancreatic-enteric anastomosis or a parenchymal leak not directly related to an anastomosis. An all-inclusive definition is a drain output of any measurable volume of fluid on or after postoperative day 3 with an amylase content greater than 3 times the serum amylase activity. Three different grades of POPF (grades A, B, C) are defined according to the clinical impact on the patient's hospital course.Conclusions. The present definition and clinical grading of POPF should allow realistic comparisons of surgical experiences in the future when new techniques, new operations, or new pharmacologic agents that may impact surgical treatment of pancreatic disorders are addressed.