Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy

Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy
复制标题

用于细胞内 mRNA 检测和光热治疗的低非特异性蛋白质吸附聚吡咯纳米探针

DOI:
10.1039/c5cc01129a
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发表时间:
2015-01-01
影响因子:
4.9
通讯作者:
Yang, Huang-Hao
Yang, Huang-Hao
中科院分区:
化学2区
文献类型:
--
作者:
Ke, Kaimei;Lin, Lisen;Yang, Huang-Hao

文献摘要

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在这项工作中,我们发现聚吡咯纳米颗粒(PPy NPs)显示出低非特异性蛋白质吸附。我们在此提出了第一个基于PPy NP的生物传感平台,用于活细胞中的细胞内mRNA检测。我们还证明了PPy NPs表现出高的NIR吸光度,并可用于癌症光热治疗。
In this work, we discovered that polypyrrole nanoparticles (PPy NPs) displayed a low non-specific protein adsorption. We herein present the first PPy NP-based biosensing platform for intracellular mRNA detection in living cells. We also demonstrate that PPy NPs exhibit high NIR absorbance and can be utilized for cancer photothermal therapy.