Molecular events in primary and metastatic colorectal carcinoma: a review.
Molecular events in primary and metastatic colorectal carcinoma: a review.
复制标题
DOI：
10.1155/2012/597497
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kanthan SC
中科院分区：
文献类型：
--
作者：
Kanthan R;Senger JL;Kanthan SC
结直肠癌（CRC）是一种异质性疾病，通过克隆选择引导的多途径事件序列发展。包括在CRC发展中的途径可大致分类为（a）基因组不稳定性，包括染色体不稳定性（CIN）、微卫星不稳定性（MSI）和CpG岛甲基化表型（CIMP），（B）基因组突变，包括肿瘤抑制基因的抑制和肿瘤癌基因的激活，（c）微小RNA，和（d）表观遗传变化。随着癌症变得更加晚期，通过上皮-间充质转化（EMT）以及额外的遗传改变促进侵袭和转移。尽管目前正在鉴定遗传和表观遗传标记，并了解参与这种疾病的发展和进展的替代途径，CRC仍然是加拿大恶性相关死亡率的第二高原因。原发性和转移性结直肠癌肿瘤发生的分子基础事件在这篇文章中有详细的描述。
Colorectal cancer (CRC) is a heterogeneous disease, developing through a multipathway sequence of events guided by clonal selections. Pathways included in the development of CRC may be broadly categorized into (a) genomic instability, including chromosomal instability (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP), (b) genomic mutations including suppression of tumour suppressor genes and activation of tumour oncogenes, (c) microRNA, and (d) epigenetic changes. As cancer becomes more advanced, invasion and metastases are facilitated through the epithelial-mesenchymal transition (EMT), with additional genetic alterations. Despite ongoing identification of genetic and epigenetic markers and the understanding of alternative pathways involved in the development and progression of this disease, CRC remains the second highest cause of malignancy-related mortality in Canada. The molecular events that underlie the tumorigenesis of primary and metastatic colorectal carcinoma are detailed in this manuscript.