Estrone, sex hormone binding globulin and lipid profiles in older women: an observational study.
Estrone, sex hormone binding globulin and lipid profiles in older women: an observational study.
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老年女性的雌酮、性激素结合球蛋白和脂质谱：一项观察性研究。
DOI：
10.1080/13697137.2023.2165908
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Islam,RM
中科院分区：
文献类型：
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作者：
Azene,ZN;Davis,SR;McNeil,JJ;Tonkin,AM;Handelsman,DJ;Islam,RM
我们调查了雌酮和性激素结合球蛋白（SHBG）浓度是否与老年绝经后妇女的脂质浓度相关。MethodsThis是一项横断面研究，涉及6358名年龄在70-95岁之间的澳大利亚妇女，在2010年至2014年期间招募。在未使用影响雌激素浓度的药物或降脂治疗的参与者中，研究了雌酮与SHBG和脂质浓度之间的关系。线性回归模型包括年龄，体重指数，吸烟，饮酒，肾功能和糖尿病，最低的四分位数（Q1）作为参考雌酮和SHBG.ResultsThe研究包括3231名参与者的中位年龄为74.0（四分位数范围71.7-77.9）年。雌酮浓度Q3和Q4与高密度脂蛋白胆固醇（HDL-C）呈正相关（分别为p= 0.017和p = 0.046）。雌酮Q4与总胆固醇呈负相关（p= 0.018），Q2和Q4与非HDL-C呈负相关（分别为p= 0.045和p = 0.002），Q3和Q4与甘油三酯呈负相关（分别为p= 0.030和p = 0.001）。对于SHBG，Q2、Q3和Q4与HDL-C呈正相关（均P < 0.001），与非HDL-C（均P = 0.001）和甘油三酯（均P < 0.001）呈负相关。性激素结合球蛋白，而不是雌酮，可能提供额外的临床预测效用的评估心脏代谢疾病的风险在老年妇女。
ObjectiveWe investigated whether estrone and sex hormone binding globulin (SHBG) concentrations are associated with lipid concentrations in older postmenopausal women.MethodsThis was a cross-sectional study of 6358 Australian women, aged 70–95 years, recruited between 2010 and 2014. Associations between estrone and SHBG and lipid concentrations were examined in participants not using medications that influence estrogen concentrations or lipid-lowering therapy. Linear regression models included age, body mass index, smoking, alcohol consumption, renal function and diabetes, with the lowest quartile (Q1) as the reference for estrone and SHBG.ResultsThe study included 3231 participants with median age of 74.0 (interquartile range 71.7–77.9) years. Estrone concentration Q3 and Q4 were positively associated with high-density lipoprotein cholesterol (HDL-C) (p= 0.017 andp= 0.046, respectively). Inverse associations were seen for estrone Q4 with total cholesterol (p= 0.018), Q2 and Q4 with non-HDL-C (p= 0.045 andp= 0.002, respectively) and Q3 and Q4 with triglycerides (p= 0.030 andp= 0.001, respectively). For SHBG, Q2, Q3 and Q4 were positively associated with HDL-C (allp< 0.001), and inversely with non-HDL-C (allp= 0.001) and triglycerides (allp< 0.001).ConclusionsEstrone and SHBG are associated with lipid concentrations in older women. SHBG, but not estrone, may provide additional clinical predictive utility for the assessment of cardiometabolic disease risk in older women.