No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene.
No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene.
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DOI：
10.3389/fendo.2013.00185
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发表时间：
2013
影响因子：
5.2
通讯作者：
Hönekopp J
中科院分区：
文献类型：
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作者：
Hönekopp J
第二个和第四个手指的长度比率(2D：4D)可能是孕期睾酮(T)效应的一个标志。AR基因CAG重复数(CAGn)与体外T敏感性呈负相关。关于2D：4D和CAGn之间的关系的结果好坏参半，但在支持和反对2D：4D有效性的争论中表现突出。在这里，我对14个相关样本进行了随机效应荟萃分析，共1904名受试者。所有研究的结果都是相同的。即使是自由估计(95%CI的上限)也接近于零，因此CAGn与右手2D：4D、左手2D：4D或两者之间的差异没有实质性关系。然而，对CAGn在体外对T依赖基因激活的影响以及CAGn与T依赖表型特征之间的关系的进一步分析表明，CAGn的正常变异性大多没有、非常小或不一致的影响。因此，CAGn和2D：4D之间缺乏明确的关联并不意味着后者作为产前T效应的标志的有效性。
The length ratio of the second to the fourth digit (2D:4D) is a putative marker of prenatal testosterone (T) effects. The number of CAG repeats (CAGn) in the AR gene is negatively correlated with T sensitivity in vitro. Results regarding the relationship between 2D:4D and CAGn are mixed but have featured prominently in arguments for and against the validity of 2D:4D. Here, I present random-effects meta-analyses on 14 relevant samples with altogether 1904 subjects. Results were homogeneous across studies. Even liberal estimates (upper limit of the 95% CI) were close to zero and therefore suggested no substantial relationship of CAGn with either right-hand 2D:4D, left-hand 2D:4D, or the difference between the two. However, closer analysis of the effects of CAGn on T dependent gene activation in vitro and of relationships between CAGn and T dependent phenotypic characteristics suggest that normal variability of CAGn has mostly no, very small, or inconsistent effects. Therefore, the lack of a clear association between CAGn and 2D:4D has no negative implications for the latter’s validity as a marker of prenatal T effects.