RESPONSE OF THE ISOLATED GALL BLADDER TO CHOLECYSTOKININ
RESPONSE OF THE ISOLATED GALL BLADDER TO CHOLECYSTOKININ
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离体胆囊对缩胆囊素的反应
DOI：
10.1152/ajplegacy.1933.103.2.275
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发表时间：
1933
影响因子：
--
通讯作者：
H. Greengard
中科院分区：
文献类型：
--
作者：
F. T. Jung;H. Greengard
图 1. 同时对豚鼠的两个离体胆囊进行追踪。下层是新鲜的；上层（活性较高）已在冰箱中放置26小时。时间信号= 30 秒； CCK=胆囊收缩素； CB= 更换浴液； j=一滴。在这种情况下，CCK 在热量的帮助下溶解在一些浴液中，引起收缩。换浴后立刻放松下来。将浴液样品加热并冷却至与 CCK 溶液平行，没有效果。乙酰胆碱引起强烈的收缩。阿托品可以阻止这种情况，之后额外的乙酰胆碱就没有效果了。更换浴液后，CCK 引起缓慢而有力的收缩，而三倍于先前剂量的阿托品也无法阻止这种收缩。收缩很缓慢，就像 Ivy 和 Oldberg 在狗身上记录的那样，并且在收缩的高度时可能会出现明显的节律性活动。在相同条件下，阿托品的剂量绝对阻止毛果芸香碱的作用，但这些收缩并未被消除。
Fig. 1. Tracing made simultaneously from two isolated gall bladders of the guinea pig. The lower was fresh; the upper (more active) had been in the refrigerator 26 hours. Time-signals= 30 seconds; CCK= cholecystokinin; CB= change of bath; j= one drop. The CCK, in this instance dissolved in some bath-fluid with the aid of heat, caused contraction. Change of bath caused immediate relaxation. A sample of bath-fluid, heated and cooled to parallel the CCK solution, had no effect. Acetyl cholin caused a strong contraction. This was stopped by atropin, after which additional acetyl cholin had no effect. After a change of bath, CCK caused a slow, powerful contraction which was not stopped by three times the previous dose of atropin.The contractions were slow, like those recorded by Ivy and Oldberg in the dog, and at the height of a contraction a marked rhythmic activity was likely to develop. These contractions were not abolished by atropin in doses which absolutely stopped the action of pilocarpin under the same conditions.