Interaction of choline and scopolamine in human memory.
Interaction of choline and scopolamine in human memory.
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胆碱和东莨菪碱在人类记忆中的相互作用。
DOI：
10.1016/0024-3205(85)90423-0
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发表时间：
1985
期刊：
影响因子：
6.1
通讯作者：
Davis,KL
中科院分区：
文献类型：
--
作者：
Mohs,RC;Davis,KL
在先前的研究(1)中，8 gm。研究发现，单次口服胆碱可以部分逆转0.43毫克东莨菪碱的遗忘和主观效应。目前的研究确定了在24小时内分4次服用14克胆碱是否也能产生类似的效果，以及在这两项研究中胆碱的作用是否与血浆胆碱浓度有关。10名正常受试者分别接受了三天的记忆测试，一次是在服用14克胆碱和0.35毫克东莨菪碱(CH-SC)后，一次是在服用安慰剂和东莨菪碱(PlSC)之后，一次是在服用安慰剂和安慰剂(PlPl)之后。东五味子碱显著损害记忆能力，但在CHSC和PlSC条件下无明显差异。无论是单剂量研究还是分剂量研究，在CHSC条件下，血浆胆碱水平均显著升高。不同研究之间的水平没有差异，记忆能力的差异也与血浆胆碱水平的升高无关。这些结果表明，任何由于饮食胆碱增加而引起的胆碱能活动的增强都是暂时的，而且幅度很小。
In a previous study (1), 8 gm. of oral choline given in a single dose were found to partially reverse the amnestic and subjective effects of 0.43 mg of scopolamine. The present study determined whether similar effects could be produced by 14 gm of choline given in 4 divided doses over 24 hrs and whether choline's effects in either study were related to plasma choline concentration. Ten normal subjects were given memory tests on three separate days, once after receiving 14 gm choline and 0.35 mg scopolamine (Ch-Sc), once following placebo and scopolamine (PlSc), and once following placebo and placebo (PlPl). Scopolamine markedly impaired memory performance but there was no difference between the ChSc and PlSc conditions. Plasma choline levels were significantly elevated in the ChSc condition of both the single dose and divided dose studies. There was no difference in levels between studies nor were differences in memory performance correlated with elevations in plasma choline. These results indicate that any enhancement of cholinergic activity due to increased dietary choline is transient and of small magnitude.