The genotoxicity of unsubstituted and nitrated polycyclic aromatic hydrocarbons.
The genotoxicity of unsubstituted and nitrated polycyclic aromatic hydrocarbons.
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发表时间：
1993-11
影响因子：
2
通讯作者：
Volker Mersch-Sundermann;S. Mochayedi;S. Kevekordes;Susanne Kern;F. Wintermann
中科院分区：
文献类型：
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作者：
Volker Mersch-Sundermann;S. Mochayedi;S. Kevekordes;Susanne Kern;F. Wintermann
为了确定非取代多环烃和取代多环烃的DNA损伤特性，我们检测了61种芳香族和杂环化合物在大肠杆菌PQ37中的诱导作用。苯并[ghi]氟蒽、苯并[j]氟蒽、苯并[c]菲、苯并[a]芘、甲苯、二苯并[a，1]芘、氟蒽和三苯等多环芳烃具有较高的遗传毒性。就硝基芳烃而言，二硝基芘表现出最高的遗传毒性。硝基芳烃的sos诱导效能由双环向四环增强。此外，我们还发现，任何硝化程度的增加都伴随着遗传毒性的增加。PAH需要肝脏细胞色素P-450酶的代谢激活，而nPAH是直接作用的基因毒物。
To determine the DNA damaging properties of unsubstituted and substituted polycyclic hydrocarbons, 61 aromatic and heterocyclic compounds were examined for the induction of the SOS system in E. coli PQ37. PAH such as benzo[ghi]fluoranthene, benzo[j]fluoranthene, benzo[c]phenanthrene, benzo[a]pyrene, chrysene, dibenzo[a,1]pyrene, fluoranthene and triphenylene showed relatively high genotoxicity. With respect to the nitroarenes, the highest genotoxic potencies were exhibited by the dinitropyrenes. The SOS-inducing potency of nitroarenes increased from the bicyclic to the tetracyclic ring system. Additionally, it was seen that any increase in the extent of nitration is paralleled by an increase of genotoxicity. Whereas PAH required metabolic activation by hepatic cytochrome P-450 enzymes, nPAH were direct-acting genotoxicants.