A NUMERICAL STUDY OF PLASMA SKIMMING IN SMALL VASCULAR BIFURCATIONS
A NUMERICAL STUDY OF PLASMA SKIMMING IN SMALL VASCULAR BIFURCATIONS
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DOI：
10.1115/1.2895708
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发表时间：
1994-02-01
影响因子：
1.7
通讯作者：
POPEL, AS
中科院分区：
文献类型：
--
作者：
ENDEN, G;POPEL, AS
部分由于血浆撇除机制，红细胞（RBC）分布到微血管分叉的分支中通常不同于大部分血流的分布。本文分析了由于红细胞在载瘤血管入口横截面上的不均匀分布而引起相分离的血浆撇除机理。在以前的研究中，通过数值模拟均匀牛顿流体在T型分叉中的三维流动，发现了将流动分成分支的表面的形状。这些发现用于本研究，以确定（作为第一近似值）侧-载瘤血管RBC流量比和排出血细胞比容比作为相应流量比的函数。计算基于以下假设：RBC沿均匀牛顿流体的流线沿着移动，并且均匀分布在母血管入口横截面处的同心核内。我们的计算结果吻合良好，在体内和体外研究的实验数据的流动参数范围很广。
Owing in part to a plasma-skimming mechanism, the distribution of red blood cells (RBCs) into branches of microvascular bifurcations typically differs from the distribution of the bulk bloodflow. This paper analyzes the plasma-skimming mechanism that causes phase separation due to uneven distribution of red blood cells at the inlet cross section of the parent vessel. In a previous study, the shape of the surface that divides the flow into the branches was found by numerical simulation of three-dimensional flow of a homogeneous Newtonian fluid in T-type bifurcations. Those findings are used in this study to determine, as a first approximation, the side-to-parent vessel RBC flux ratio and discharge hematocrit ratio as a function of corresponding flow ratios. Calculations are based on the assumption that RBCs move along streamlines of a homogeneous Newtonian fluid and are uniformly distributed within a concentric core at the inlet cross section of the parent vessel. The results of our calculations agree well for a wide range of flow parameters with experimental data from in vivo and in vitro studies.