Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism.
Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism.
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DOI：
10.1093/cercor/bhw417
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发表时间：
2017-02-01
期刊：
影响因子：
--
通讯作者：
Simons JS
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文献类型：
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作者：
Cooper RA;Richter FR;Bays PM;Plaisted-Grant KC;Baron-Cohen S;Simons JS
最近越来越多的研究试图了解自闭症谱系障碍（ASD）个体所经历的回忆障碍。在这里，我们测试了这些记忆缺陷是否反映了检索成功的概率或记忆表征的精度降低。我们还使用功能性磁共振成像（fMRI）来研究ASD中记忆编码和提取的神经机制，特别关注核心情景记忆网络的功能连接。患有ASD的成年人和典型的对照组参与者完成了一项记忆任务，该任务涉及研究视觉显示，随后使用连续拨号来重现他们的外观。ASD组的检索成功率降低，但没有证据表明检索精度存在差异。功能磁共振成像数据显示，在两组记忆编码过程中，大脑活动和功能连接的模式相似，尽管编码相关的侧额叶活动仅在对照组中预测随后的检索成功。在记忆提取过程中，ASD组表现出侧额叶活动减弱，海马连接大幅减少，特别是海马和额顶叶控制网络区域之间的连接。这些研究结果表明，在情节记忆检索在ASD的脑功能显着差异，并强调功能连接的重要性，以了解在这一人群中的回忆相关的检索缺陷。
Increasing recent research has sought to understand the recollection impairments experienced by individuals with autism spectrum disorder (ASD). Here, we tested whether these memory deficits reflect a reduction in the probability of retrieval success or in the precision of memory representations. We also used functional magnetic resonance imaging (fMRI) to study the neural mechanisms underlying memory encoding and retrieval in ASD, focusing particularly on the functional connectivity of core episodic memory networks. Adults with ASD and typical control participants completed a memory task that involved studying visual displays and subsequently using a continuous dial to recreate their appearance. The ASD group exhibited reduced retrieval success, but there was no evidence of a difference in retrieval precision. fMRI data revealed similar patterns of brain activity and functional connectivity during memory encoding in the 2 groups, though encoding-related lateral frontal activity predicted subsequent retrieval success only in the control group. During memory retrieval, the ASD group exhibited attenuated lateral frontal activity and substantially reduced hippocampal connectivity, particularly between hippocampus and regions of the fronto-parietal control network. These findings demonstrate notable differences in brain function during episodic memory retrieval in ASD and highlight the importance of functional connectivity to understanding recollection-related retrieval deficits in this population.