Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in type 2 diabetes
Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in type 2 diabetes
复制标题
DOI：
10.2337/diacare.28.10.2458
复制
发表时间：
2005-10-01
期刊：
影响因子：
16.2
通讯作者：
Hosseini, M
中科院分区：
文献类型：
--
作者：
Farvid, MS;Jalali, M;Hosseini, M
目的：本研究旨在评估镁加锌、维生素C加E以及这些微量营养素组合对2型糖尿病患者肾病指标的影响。研究设计与方法：在一项随机、双盲、安慰剂对照的临床试验中，69例2型糖尿病患者被随机分为4组，每组接受以下补充剂中的一组，持续3个月：M组（n = 16）， 200 mg mg和30 ing Zn；V组（n = 18）， 200 mg维生素C和100 IU维生素E；W组（n 17），矿物质加维生素；P组（n = 18）为安慰剂。在试验开始和结束时测定尿白蛋白排泄量和尿中n -乙酰- β - d -氨基葡萄糖酶活性（NAG）。采用一般线性模型分析处理效果。结果-结果表明，添加3个月后，V组和MV组尿白蛋白排泄水平下降（P = 0.034和P = 0.005）。尿NAG活性在任何治疗组均无显著变化。MV组收缩压、舒张压和平均血压水平显著降低（P = 0.008、P = 0.017和P = 0-009）。此外，维生素和矿物质联合补充在降低空腹血糖（P = 0.035）和丙二醛浓度（P = 0.004）以及提高高密度脂蛋白胆固醇和载脂蛋白Al水平（P = 0.019）方面也有显著作用。在其他三组中，这些参数的水平没有显著变化。结论-总之，本研究的结果为维生素C和E以及镁、锌和维生素C和E联合补充对2型糖尿病患者肾小球肾功能的改善而不是小管肾功能的改善提供了证据。
OBJECTIVE - The present study was designed to assess the effect of magnesium plus zinc, vitamins C plus E, and a combination of these micronutrients on nephropathy indexes in type 2 diabetic patients.RESEARCH DESIGN AND METHODS - in a randomized, double-blind, placebo-controlled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups, each group receiving one of the following daily supplement for 3 months: group M (n = 16), 200 mg Mg and 30 ing Zn; group V (n = 18), 200 mg vitamin C and 100 IU vitamin E; group W (n 17), minerals plus vitamins; and group P (n = 18), placebo. Urinary albumin excretion and N-acetyl-beta-D-glucosaminidase activity (NAG) in urine were determined at the beginning and at the end of the trial. Treatment effects were analyzed by general linear modeling.RESULTS - Results indicate that after 3 months of supplementation, levels of urinary albumin excretion decreased in the V and MV groups (P = 0.034 and P = 0.005, respectively). Urinary NAG activity did not significantly change in any treatment groups. Levels of systolic, diastolic, and mean blood pressure significantly decreased in the MV group (P = 0.008, P = 0.017, and P = 0-009, respectively). Also, combination of vitamin and mineral supplementation had significant effects in decreasing fasting serum glucose (P = 0.035) and malonclialdehyde concentrations (P = 0.004) and in increasing HDL cholesterol and apolipoprotein Al levels (P = 0.019). There was no significant change in the levels of these parameters in the other three groups.CONCLUSIONS - in conclusion, the results of the present study provide evidence for the effects of vitamins C and E and also combination of magnesium, zinc, and vitamins C and E supplementation on improvement of glomerular but not tubular renal function in type 2 diabetic patients.