Effect of ALDH2 polymorphism on cancer risk in Asians A meta-analysis
Effect of ALDH2 polymorphism on cancer risk in Asians A meta-analysis
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DOI：
10.1097/md.0000000000014855
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发表时间：
2019-03-01
期刊：
影响因子：
1.6
通讯作者：
Zeng, Shanggan
中科院分区：
文献类型：
--
作者：
Zuo, Wei;Zhan, Zhenyu;Zeng, Shanggan
大量研究表明ALDH 2基因rs671 G>A多态性与亚洲人多种癌症类型的相关性。然而，结果仍然不确定。我们进行了一项综合荟萃分析，包括63篇文章，66项研究，包含25，682例病例和47，455例对照，检索PubMed和Embase电子数据库，截至2018年3月5日。汇总结果表明，ALDH 2基因rs671多态性与亚洲人的总体癌症风险显著相关（纯合子模型：比值比[OR] =0.85，95%置信区间[CI]=0.72-0.99，P= 0.042;杂合子模型：OR=1.32，95% CI=1.14-1.52，P
Numerous studies have investigated the association between ALDH2 gene rs671G>A polymorphism and various cancer type in Asians. However, the results remain inconclusive.We conducted a comprehensive meta-analysis including 63 articles with 66 studies containing 25,682 cases and 47,455 controls retrieved by searching PubMed and Embase electronic databases up to March 5, 2018.Pooled results indicated that ALDH2 gene rs671 polymorphism was significantly associated with the overall cancer risk in Asians (homozygous model: odds ratio [OR] =0.85, 95% confidence interval [CI]=0.72-0.99, P=.042; heterozygous model: OR=1.32, 95% CI=1.14-1.52, P